Results 121 to 130 of about 125,979 (217)

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Correction to: Episodic Ataxia Type 1: Natural History and Effect on Quality of Life. [PDF]

Cerebellum, 2023
Graves TD, Griggs RC, Bundy BN, Jen JC, Baloh RW, Hanna MG, CINCH Investigators.   +6 more
europepmc   +1 more source

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source

Sensorimotor processing for balance in spinocerebellar ataxia type 6. [PDF]

, 2015
We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities.
Voyce, DC, Marsden, JF, Day, BL, Bunn, LM, Giunti, P   +4 more
core  

Paroxysmal neurological spells in TANGO2 deficiency disorder: a case report and a scoping review

Frontiers in Pediatrics
BackgroundTANGO2 deficiency disorder (TDD) is a rare autosomal recessive condition characterized by neurodevelopmental impairment and recurrent metabolic crises. Paroxysmal non-epileptic neurological episodes (“TANGO2 spells”) are increasingly recognized
Emanuela Claudia Turco, Giulia Pisanò, Silvia Carestiato, Laura Caiazza, Benedetta Piccolo, Carlo Fusco, Susanna Esposito, Maria Carmela Pera   +7 more
doaj   +1 more source

Vertical Saccadic Slowing in Episodic Ataxia Type 2. [PDF]

J Clin Neurol, 2022
Kim S, Kim S, Lee S, Kim HJ.
europepmc   +1 more source

Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Vestibular migraine (VM) is a common cause of intermittent dizziness, but there have been no studies with provoked (induced) VM used to characterize how the vestibular and ocular (vision) systems interact. We injected 20 patients with VM with nitroglycerin to provoke an attack and used a specialized camera to record their eye ...
Maria Dolores Villar‐Martinez, Francesca Puledda, Caroline Domingos‐Belo, Adolfo M. Bronstein, Peter J. Goadsby   +4 more
wiley   +1 more source

An activator of voltage-gated K⁺ channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1. [PDF]

Proc Natl Acad Sci U S A, 2023
Servettini I, Talani G, Megaro A, Setzu MD, Biggio F, Briffa M, Guglielmi L, Savalli N, Binda F, Delicata F, Bru-Mercier G, Vassallo N, Maglione V, Cauchi RJ, Di Pardo A, Collu M, Imbrici P, Catacuzzeno L, D'Adamo MC, Olcese R, Pessia M.   +20 more
europepmc   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1. [PDF]

Cells, 2023
Martin HGS, Kullmann DM.
europepmc   +1 more source