Results 131 to 140 of about 125,979 (217)

Concurrent Use of Tasipimidine Oral Solution and Fluoxetine in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dogs (n = 8; 4 dogs per dose level), with a 7‐day washout between phases. Dogs received single oral doses of
Jenni Lindstedt, Jouko M. Levijoki, Johanna Tuunainen, Jens Häggström, Meri Ramela, Mira Korpivaara   +5 more
wiley   +1 more source

Three novel KCNA1 mutations in episodic ataxia type I families

, 1998
Hereditary paroxysmal ataxia, or episodic ataxia (EA), is a rare, genetically heterogeneous neurological disorder characterized by attacks of generalized ataxia.
Verlind, E, Stulp, RP, van der Vlies, P, Scheffer, H, Hofstra, RMW, Buys, CHCM, Brunt, ERP, Mantel, G, Mol, GJJ, Averyanov, YN   +9 more
core  

Identification and characterisation of pathogenic and non-pathogenic FGF14 repeat expansions

Nature Communications
Repeat expansions in FGF14 cause autosomal dominant late-onset cerebellar ataxia (SCA27B) with estimated pathogenic thresholds of 250 (incomplete penetrance) and 300 AAG repeats (full penetrance), but the sequence of pathogenic and non-pathogenic ...
Lars Mohren, Friedrich Erdlenbruch, Elsa Leitão, Fabian Kilpert, G. Sebastian Hönes, Sabine Kaya, Christopher Schröder, Andreas Thieme, Marc Sturm, Joohyun Park, Agatha Schlüter, Montserrat Ruiz, Moisés Morales de la Prida, Carlos Casasnovas, Kerstin Becker, Ulla Roggenbuck, Sonali Pechlivanis, Frank J. Kaiser, Matthis Synofzik, Thomas Wirth, Mathieu Anheim, Tobias B. Haack, Paul J. Lockhart, Karl-Heinz Jöckel, Aurora Pujol, Stephan Klebe, Dagmar Timmann, Christel Depienne   +27 more
doaj   +1 more source

Episodic ataxia type 2 (EA2) with interictal myokymia and focal dystonia. [PDF]

Cold Spring Harb Mol Case Stud, 2022
Nielsen EN, Ásbjörnsdóttir B, Møller LB, Nielsen JE, Lindquist SG.   +4 more
europepmc   +1 more source

Identification of Lupus Erythematosus Cells and Ragocytes in Peripheral Blood from a Dog with Systemic Lupus Erythematosus

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 3‐year‐old female‐intact German Shepherd presented for the evaluation of progressive shifting leg lameness, carpal swelling, and weight loss with a poor appetite since adoption about three months prior. Routine blood smear evaluation, lymph node, and synovial fluid cytologies all revealed rare neutrophils with cytoplasmic inclusions ...
Samantha L. Braman, Jeremy P. Bessett, Katie L. Anderson, Kristen R. Friedrichs   +3 more
wiley   +1 more source

Apo state pore opening as functional basis of increased EAAT anion channel activity in episodic ataxia 6. [PDF]

Front Physiol, 2023
Suslova M, Kortzak D, Machtens JP, Kovermann P, Fahlke C.   +4 more
europepmc   +1 more source

Infection with the Neorickettsial Organism Stellantchasmus falcatus Agent in an Arctic Fox (Vulpes lagopus)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 1‐year‐old female‐intact arctic fox (Vulpes lagopus) presented for diarrhea, lethargy, severe thrombocytopenia, and hyperbilirubinemia. Blood film evaluation revealed intracytoplasmic coccoid bacteria within moderate numbers of leukocytes consistent with infection by a rickettsial organism.
Jeremy P. Bessett, Alexis G. Davidson, Alyssa M. Scagnelli, Kristen R. Friedrichs   +3 more
wiley   +1 more source

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6. [PDF]

Nat Commun, 2023
Colucci E, Anshari ZR, Patiño-Ruiz MF, Nemchinova M, Whittaker J, Slotboom DJ, Guskov A.   +6 more
europepmc   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Episodic Ataxia Type 1: Natural History and Effect on Quality of Life. [PDF]

Cerebellum, 2023
Graves TD, Griggs RC, Bundy BN, Jen JC, Baloh RW, Hanna MG, CINCH Investigators.   +6 more
europepmc   +1 more source