Results 121 to 130 of about 50,815 (199)
Universality classes of interaction structures for NK fitness landscapes
, 2018 Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca +3 more
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Frontiers in Genetics, 2019 The one-century-old theory of orthogonal genetic variance decomposition originated the field of quantitative genetics and has kept on being improved ever since.
José M. Álvarez-Castro +1 more
doaj +1 more source
Determination of Nonlinear Genetic Architecture using Compressed Sensing
, 2015 We introduce a statistical method that can reconstruct nonlinear genetic models (i.e., including epistasis, or gene-gene interactions) from phenotype-genotype (GWAS) data.
Ho, Chiu Man, Hsu, Stephen D. H.
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BMC Bioinformatics, 2018 Background Genetic epistasis is an often-overlooked area in the study of the genomics of complex traits. Genome-wide association studies are a useful tool for revealing potential causal genetic variants, but in this context, epistasis is generally ...
Victor A. O. Carmelo +3 more
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Robustness and epistasis in mutation-selection models
, 2009 We investigate the fitness advantage associated with the robustness of a phenotype against deleterious mutations using deterministic mutation-selection models of quasispecies type equipped with a mesa shaped fitness landscape.
Andrea Wolff +11 more
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3D protein structure from genetic epistasis experiments
, 2018 SummaryHigh-throughput experimental techniques have made possible the systematic sampling of the single mutation landscape for many proteins, defined as the change in protein fitness as the result of point mutation sequence changes. In a more limited number of cases, and for small proteins only, we also have nearly full coverage of all possible double ...
Rollins, Nathan J. +6 more
openaire +1 more source
Distributed transformer for high order epistasis detection in large-scale datasets
Scientific ReportsUnderstanding the genetic basis of complex diseases is one of the most important challenges in current precision medicine. To this end, Genome-Wide Association Studies aim to correlate Single Nucleotide Polymorphisms (SNPs) to the presence or absence of ...
Miguel Graça +3 more
doaj +1 more source
Reducing Epistasis and Pleiotropy Can Avoid the Survival of the Flattest Tragedy
BiologyThis study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape.
Priyanka Mehra, Arend Hintze
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Partnering Strategies for Fitness Evaluation in a Pyramidal Evolutionary Algorithm
, 2008 This paper combines the idea of a hierarchical distributed genetic algorithm with different inter-agent partnering strategies. Cascading clusters of sub-populations are built from bottom up, with higher-level sub-populations optimising larger parts of ...
Aickelin, Uwe, Bull, Larry
core
Considerations in the search for epistasis
Genome BiologyEpistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units.
Marleen Balvert +26 more
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