Results 121 to 130 of about 58,973 (229)
Selection biases the prevalence and type of epistasis along adaptive trajectories [PDF]
arXiv, 2012 The contribution to an organism's phenotype from one genetic locus may depend upon the status of other loci. Such epistatic interactions among loci are now recognized as fundamental to shaping the process of adaptation in evolving populations. Although little is known about the structure of epistasis in most organisms, recent experiments with bacterial
arxiv
Complexity of evolutionary equilibria in static fitness landscapes [PDF]
, 2013 A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reaching equilibrium only if a local ...
Kaznatcheev, Artem
core
The impact of macroscopic epistasis on long-term evolutionary dynamics [PDF]
arXiv, 2014 Genetic interactions can strongly influence the fitness effects of individual mutations, yet the impact of these epistatic interactions on evolutionary dynamics remains poorly understood. Here we investigate the evolutionary role of epistasis over 50,000 generations in a well-studied laboratory evolution experiment in E. coli. The extensive duration of
arxiv
Epistasis and Shapes of Fitness Landscapes [PDF]
, 2006 The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions.
Beerenwinkel, Niko +2 more
core +4 more sources
3D protein structure from genetic epistasis experiments [PDF]
, 2018 SummaryHigh-throughput experimental techniques have made possible the systematic sampling of the single mutation landscape for many proteins, defined as the change in protein fitness as the result of point mutation sequence changes. In a more limited number of cases, and for small proteins only, we also have nearly full coverage of all possible double ...
Rollins, Nathan J. +6 more
openaire +1 more source
Epistasis not needed to explain low dN/dS
, 2012 An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern +19 more
core +1 more source
Epistasis and immunity: the role of genetic interactions in autoimmune diseases
Immunology, 2012 SummaryAutoimmune disorders are a complex and varied group of diseases that are caused by breakdown of self‐tolerance. The aetiology of autoimmunity is multi‐factorial, with both environmental triggers and genetically determined risk factors. In recent years, it has been increasingly recognized that genetic risk factors do not act in isolation, but ...
Anna M. Rose, Lucy C K Bell
openaire +4 more sources
Poor statistical power in population-based association study of gene interaction
BMC Medical GenomicsBackground Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype.
Jiarui Ma +4 more
doaj +1 more source
BioData Mining, 2019 Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants.
Marc Joiret +3 more
doaj +1 more source
Privacy-preserving decision tree for epistasis detection
Cybersecurity, 2019 The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj +1 more source