Results 131 to 140 of about 58,973 (229)
The Origin of Mutational Epistasis [PDF]
arXivThe interconnected processes of protein folding, mutations, epistasis, and evolution have all been the subject of extensive analysis throughout the years due to their significance for structural and evolutionary biology. The origin (molecular basis) of epistasis (the non-additive interactions between mutations) is still, nonetheless, unknown.
arxiv
Shared information between residues is sufficient to detect pair-wise epistasis in a protein [PDF]
PLoS Genetics 12 (2016) e1006471, 2016 In a comment on our manuscript "Strong selection significantly increases epistatic interactions in the long-term evolution of a protein", Dr. Crona challenges our assertion that shared entropy (that is, information) between two residues implies epistasis between those residues, by constructing an explicit example of three loci (say A, B, and C), where ...
arxiv
The evolution of genetic architectures underlying quantitative traits
, 2013 In the classic view introduced by R. A. Fisher, a quantitative trait is encoded by many loci with small, additive effects. Recent advances in QTL mapping have begun to elucidate the genetic architectures underlying vast numbers of phenotypes across ...
Plotkin, Joshua B., Rajon, Etienne
core +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2013 Introducción. La hipertensión arterial es una enfermedad multifactorial influenciada por componentes genéticos y ambientales, cuya prevalencia varía entre grupos étnicos.
Diana María Valencia +6 more
doaj +1 more source
Fixation of mutators in asexual populations: the role of genetic drift and epistasis [PDF]
Evolution 67, 1143 (2013), 2012 We study the evolutionary dynamics of an asexual population of nonmutators and mutators on a class of epistatic fitness landscapes. We consider the situation in which all mutations are deleterious and mutators are produced from nonmutators continually at a constant rate.
arxiv
Frontiers in Genetics, 2019 The one-century-old theory of orthogonal genetic variance decomposition originated the field of quantitative genetics and has kept on being improved ever since.
José M. Álvarez-Castro +1 more
doaj +1 more source
'On the Application of Hierarchical Coevolutionary Genetic Algorithms: Recombination and Evaluation Partners' [PDF]
, 2003 This paper examines the use of a hierarchical coevolutionary genetic algorithm under different partnering strategies. Cascading clusters of sub-populations are built from the bottom up, with higher-level sub-populations optimising larger parts of the ...
Aickelin, Uwe, Bull, Larry
core +5 more sources
Correction: From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis
PLoS Genetics, 2008 Table 1b is not displayed correctly in the published article. Please see the correct Table 1 here:
David L. Aylor, Zhao-Bang Zeng
openaire +4 more sources
A complete classification of epistatic two-locus models [PDF]
arXiv, 2006 The study of epistasis is of great importance in statistical genetics in fields such as linkage and association analysis and QTL mapping. In an effort to classify the types of epistasis in the case of two biallelic loci Li and Reich listed and described all models in the simplest case of 0/1 penetrance values.
arxiv
Epistasis-based Basis Estimation Method for Simplifying the Problem Space of an Evolutionary Search in Binary Representation [PDF]
arXiv, 2019 An evolutionary search space can be smoothly transformed via a suitable change of basis; however, it can be difficult to determine an appropriate basis. In this paper, a method is proposed to select an optimum basis can be used to simplify an evolutionary search space in a binary encoding scheme.
arxiv