Results 91 to 100 of about 27,549 (205)

Considerations in the search for epistasis

Genome Biology
Abstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive ...
Balvert, M., Cooper-Knock, J., Stamp, J., Byrne, R.P., Mourragui, S., van Gils, J., Benonisdottir, S., Schlüter, J., Kenna, K., Abeln, S., Iacoangeli, A., Daub, J.T., Browning, B.L., Taş, G., Hu, J., Wang, Y., Alhathli, E., Harvey, C., Pianesi, L., Schulte, S.C., González-Domínguez, J., Garrisson, E., Al-Chalabi, A., Cartes, J.A., Baaijens, J., von Berg, J., Bolognini, D., Bonizzoni, P., Guarracino, A., Koyuturk, M., Markowska, M., Dandinasivara, R., van Bemmelen, J., Vorbrugg, S., Zhang, S., Pasanuic, B., Snyder, M.P., Schönhuth, A., Sng, L.M.F., Twine, N.A.   +39 more
openaire   +7 more sources

Genetic analyses of leaf traits in an interspecific Zoysia japonica × Zoysia matrella F2 population

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Zoysiagrass (Zoysia spp.) is an important warm‐season turfgrass cultivated across tropical, subtropical, and temperate regions of the world. The genus is characterized by the presence of salt‐secreting glands on the adaxial leaf surface, which contribute to its high salt tolerance.
Shreena Pradhan, Thomas H. Pendergast IV, John J. Spiekerman, John H. Lagergren, Daniel A. Jacobson, Katrien M. Devos   +5 more
wiley   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, Volume 183, Issue 17, Page 5211-5229, September 2026.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

GhSCAMP13 Negatively Modulates Salt Tolerance Through GhNHX7b‐Dependent Na+ Homeostasis in Cotton

Plant Biotechnology Journal, EarlyView.
Haohong Tang, Zhaojie He, Cong Sun, Haonan Shi, Zhan Gao, Yanlong Jin, Wenting Ji, Linfu Feng, Ning Wang, Zunzhe Tian, Guanjing Hu, Jie Sun, Xianpeng Xiong   +12 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Patient‐Derived Organoid‐Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance

Nature Communications
Pre-existing mutations can influence subsequent evolution by constraining or opening evolutionary pathways through epistatic interactions. In some cases, global epistasis allows evolutionary pathways to be predicted from the fitness of the genetic ...
Gabriela Petrungaro, Theresa Fink, Booshini Fernando, Gerrit Ansmann, Tobias Bollenbach   +4 more
doaj   +1 more source

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of insulin resistance in obesity.
Natasha Jaiswal, Matthew Gavin, Louise Lantier, Olivia Yu Yu Ong, David H. Wasserman, Paul M. Titchenell   +5 more
wiley   +1 more source

Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis

Nature Communications
Epistasis - the interaction between alleles at different genetic loci - plays a fundamental role in biology. However, several recent approaches quantify epistasis using a chimeric formula that measures deviations from a multiplicative fitness model on an
Uthsav Chitra, Brian Arnold, Benjamin J. Raphael   +2 more
doaj   +1 more source