Results 91 to 100 of about 68,669 (249)
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source
Nonparametric method for genomics-based prediction of performance of quantitative traits involving epistasis in plant breeding. [PDF]
PLoS ONE, 2012 Genomic selection (GS) procedures have proven useful in estimating breeding value and predicting phenotype with genome-wide molecular marker information.
Xiaochun Sun, Ping Ma, Rita H Mumm
doaj +1 more source
Epistasis and Shapes of Fitness Landscapes [PDF]
, 2006 The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions.
Beerenwinkel, Niko +2 more
core +4 more sources
Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model
, 2014 The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume +3 more
core +1 more source
Higher-order epistasis and phenotypic prediction
bioRxiv, 2020 Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element.
Juannan Zhou +5 more
semanticscholar +1 more source
Structural Variations Contribute to Subspeciation and Yield Heterosis in Rice
Plant Biotechnology Journal, EarlyView.ABSTRACT Yield heterosis has been extensively exploited in hybrid breeding, with intersubspecific hybrids often exhibiting the most pronounced effects. However, developing elite hybrids remains a laborious and time‐consuming process. The genetic basis of heterosis has been debated for over a century, hindered largely by the lack of high‐quality genomes.
Zhiwu Dan, Yunping Chen, Wenchao Huang
wiley +1 more source
Epistasis detectably alters correlations between genomic sites in a narrow parameter window.
PLoS ONE, 2019 Different genomic sites evolve inter-dependently due to the combined action of epistasis, defined as a non-multiplicative contribution of alleles at different loci to genome fitness, and the physical linkage of different loci in genome.
Gabriele Pedruzzi, Igor M Rouzine
doaj +1 more source
Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1. [PDF]
PLoS ONE, 2011 Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation ...
Javier P Martínez +6 more
doaj +1 more source
Statistical Physics of Evolutionary Trajectories on Fitness Landscapes [PDF]
, 2013 Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landscapes determine population fates and thus play a central role in ...
Manhart, Michael, Morozov, Alexandre V.
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant‐derived secondary metabolites act as regulators of in planta defence. Plant phenylpropanoid metabolic compounds, including final metabolites such as lignin and flavonoids, and a few intermediate metabolites play critical roles in defence.
Dan Chen +9 more
wiley +1 more source