Results 91 to 100 of about 37,358 (239)

Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana, Yiwen Li, Braulio Carrillo Sanchez, Ayesha Khan, Paul A. Dalby   +4 more
wiley   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

iMetaOmics, EarlyView.
Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang, Yirong Wei, Xiaoping Guo, Ruimen Zhang, Yingming Wei, Yanna Huang, Qinyang Jiang   +6 more
wiley   +1 more source

Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis

BioData Mining
Purpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all
Sandra Batista, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer, Jason H. Moore   +8 more
doaj   +1 more source

Privacy-preserving decision tree for epistasis detection

Cybersecurity, 2019
The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
doaj   +1 more source

Translating Riedl: The Circulation and Operationalisation of Evolutionary Ideas

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Rupert Riedl's Order in Living Organisms proposed a systems theory of evolution decades before the concepts it pioneered—homology, burden, the imitative epigenotype—reached the agenda of evolutionary biology. This paper reconstructs the lineages that operationalized his insights across several fields and explores the internal and external reasons for ...
Laura Nuño de la Rosa
wiley   +1 more source

Epistasis correlates to genomic complexity

, 2006
4 pages, 2 figures.-- Additional information (Suppl. Table S2: Synopsis of the studies seeking for epistasis between deleterious mutations, and Suppl. text: Possible factors that could have led to an artefactual correlation between epistasis and genome ...
Elena, Santiago F., Sanjuán, Rafael
core   +1 more source

Impact of plant breeding on the responsiveness of maize and wheat varieties to an arbuscular mycorrhizal fungal symbiont

PLANTS, PEOPLE, PLANET, EarlyView.
Field inoculation with arbuscular mycorrhizal fungi (AMF) offers a promising route to improve sustainable agriculture and food production, yet results are often variable. We investigated the mycorrhizal growth response of maize and wheat varieties recommended for farmers and found substantial variation under greenhouse conditions.
Ido Rog, Marco Malinowski, Dylan Baumann, Raphaël Boussageon, Stefanie Lutz, Marcel G. A. van der Heijden   +5 more
wiley   +1 more source

Genomic architecture and breeding trade‐offs of coconut drought tolerance

PLANTS, PEOPLE, PLANET, EarlyView.
The coconut palm is an extremely popular and economically important crop, with around 65 million tonnes produced in 2023. Although Africa's coconut sector is growing rapidly, it—and the livelihoods that depend on it—is threatened by climate change, particularly increased drought.
Theodore S. Brook, Tom Versluys, Bi Tra Serges Doubi, Sam Acors, Jahcub Trew, Kyle Macleod, Louis Bell‐Roberts, Katarina Piponi, Jean Louis Konan, Konan Engueran Djaha, Hala N'klo, Benjamin J. Roberts, Catherine M. Collins, Matteo Fumagalli, Julien Godwin, Vincent Savolainen   +15 more
wiley   +1 more source

The Case | Epistasis and urolithiasis

Kidney International, 2017
A 26-year-old woman was referred for recurrent urolithiasis. The first manifestation occurred 3 years before, followed by recurrent acute episodes. She underwent one ureteral stent placement, one shock wave lithotripsy, and at last a flexible ureteroscopy that allowed to retrieve all the remaining stones.
Tabibzadeh, Nathalie, Cheddani, Lynda, Daudon, Michel, Haymann, Jean-Philippe, Toussaint, Aurélie, Silve, Caroline, Letavernier, Emmanuel   +6 more
openaire   +3 more sources