Results 81 to 90 of about 37,358 (239)
G3: Genes, Genomes, Genetics, 2019 Epistasis is an important contributor to genetic variance. In inbred populations, pairwise epistasis is present as additive by additive interactions.
Nicholas Santantonio +2 more
doaj +1 more source
Influence of epistasis on response to genomic selection using complete sequence data
Genetics Selection Evolution, 2017 Background The effect of epistasis on response to selection is a highly debated topic. Here, we investigated the impact of epistasis on response to sequence-based selection via genomic best linear prediction (GBLUP) in a regime of strong non-symmetrical ...
Natalia S. Forneris +3 more
doaj +1 more source
Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins. [PDF]
PLoS ONE, 2016 Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of ...
Erik D Nelson, Nick V Grishin
doaj +1 more source
, 2014 (A) MAPK pathway models depicting the secondary screen assays used to conduct the epistasis analysis. See Text S1 for full secondary assay information. (B) Epistasis screen results are shown for bona fide MAPK pathway components as well as a selection of
Sébastien Lemieux (21612) +10 more
core +1 more source
Animal Research and One Health, EarlyView.vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul +6 more
wiley +1 more source
Epigenetics, epistasis and epidemics [PDF]
Evolution, Medicine, and Public Health, 2013 Department of Microbiology, Ramon y Cajal University Hospital, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain *Correspondence address. Department of Microbiology, Ramon y Cajal University Hospital, Carretera de Colmenar km 9,100. 28034 Madrid, Spain.
openaire +2 more sources
Neurology, 2009 Recent studies in multiple sclerosis (MS) have taken epistasis from speculation and expectation to the reality of its key roles in susceptibility and outcome. Bateson1 first used the term epistasis to describe the effects on a biologic trait of one gene masking another.
Ramagopalan, S, Ebers, G
openaire +3 more sources
Evaluating Methods for Modeling Epistasis Networks with Application to Head and Neck Cancer
Cancer Informatics, 2015 Epistasis helps to explain how multiple single-nucleotide polymorphisms (SNPs) interact to cause disease. A variety of tools have been developed to detect epistasis.
Rajesh Talluri, Sanjay Shete
doaj +1 more source
, 2005 [Resumen] En esta memoria se profundiza en el análisis del concepto de epistasis, Se muestra como -conjuntamente con el orden de una función - la epistasis permite explicar el comportamiento de algunas funciones cuyos extremos son conocidos (y su ...
Suárez Peñaranda, Vicente
core
, 2015 Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Kristina Crona (567679)
core +1 more source