Results 61 to 70 of about 68,669 (249)
Mathematics, 2020 Epistasis, which indicates the difficulty of a problem, can be used to evaluate the basis of the space in which the problem lies. However, calculating epistasis may be challenging as it requires all solutions to be searched.
Yong-Hoon Kim +2 more
doaj +1 more source
A general model for multilocus epistatic interactions in case-control studies. [PDF]
PLoS ONE, 2010 BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases.
Zhong Wang +5 more
doaj +1 more source
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Nature Communications, 2020 Genetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with subsequent evolutionary adaptation to the drug?
Marta Lukačišinová +2 more
semanticscholar +1 more source
Genes, 2021 Epistasis is widely considered important, but epistasis studies lag those of SNP effects. Genome-wide association study (GWAS) using 76,109 SNPs and 294,079 first-lactation Holstein cows was conducted for testing pairwise epistasis effects of five ...
Dzianis Prakapenka +4 more
semanticscholar +1 more source
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
Nature Communications, 2020 About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization.
E. Girardi +17 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang +14 more
wiley +1 more source
Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
doaj +1 more source
Epistasis between antibiotic tolerance, persistence, and resistance mutations
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The failure of antibiotic treatment is a major concern worldwide. Resistance is a main determinant in the survival of bacteria under antibiotics.
Irit Levin-Reisman +3 more
semanticscholar +1 more source
Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories
Nature Ecology & Evolution, 2020 Patterns of epistasis and shapes of fitness landscapes are of wide interest because of their bearings on a number of evolutionary theories. The common phenomena of slowing fitness increases during adaptations and diminishing returns from beneficial ...
Daniel M. Lyons +3 more
semanticscholar +1 more source
EpiMOGA: An Epistasis Detection Method Based on a Multi-Objective Genetic Algorithm
Genes, 2021 In genome-wide association studies, detecting high-order epistasis is important for analyzing the occurrence of complex human diseases and explaining missing heritability. However, there are various challenges in the actual high-order epistasis detection
Yuan-yuan Chen +7 more
semanticscholar +1 more source