Results 61 to 70 of about 37,358 (239)
, 2017 Standardized genotypic values are shown for the nine genotype combinations at a pair of loci. Values were standardized by dividing them by the square root of the residual variance from the base model.
Yuanmei Guo (136701) +1 more
core +1 more source
Epistatic interactions alter dynamics of multilocus gene-for-gene coevolution. [PDF]
PLoS ONE, 2007 Fitness costs associated with resistance or virulence genes are thought to play a key role in determining the dynamics of gene-for-gene (GFG) host-parasite coevolution. However, the nature of interactions between fitness effects of multiple resistance or
Andy Fenton, Michael A Brockhurst
doaj +1 more source
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
PLoS ONE, 2011 Genome-wide association (GWA) studies have identified a number of loci underlying variation in human serum uric acid (SUA) levels with the SLC2A9 gene having the largest effect identified so far.
Wenhua Wei +17 more
doaj +1 more source
Nonparametric method for genomics-based prediction of performance of quantitative traits involving epistasis in plant breeding. [PDF]
PLoS ONE, 2012 Genomic selection (GS) procedures have proven useful in estimating breeding value and predicting phenotype with genome-wide molecular marker information.
Xiaochun Sun, Ping Ma, Rita H Mumm
doaj +1 more source
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]
, 2012 Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Darina Czamara +63 more
core +2 more sources
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source
Comput. Artif. Intell., 1999 Normalized epistasis measures links between separate bits in binary strings. It is used in optimization. Unitarian functions (fitness functions \(f\) whose values depends only upon the number of ones rep. zeros in the optimized binary string) with extreme epistasis are theoretically studied. The epistasis of a binary string \(s = s_{l - 1} \cdots s_0\)
Iglesias, M. T. +3 more
openaire +2 more sources
Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1. [PDF]
PLoS ONE, 2011 Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation ...
Javier P Martínez +6 more
doaj +1 more source
Global epistasis on fitness landscapes [PDF]
, 2022 Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are often thought of as detrimental to our ability to predict evolution.
Diaz-Colunga, Juan +8 more
core +1 more source