Results 51 to 60 of about 37,358 (239)
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
Epistasis in protein evolution [PDF]
Protein Science, 2016 AbstractThe structure, function, and evolution of proteins depend on physical and genetic interactions among amino acids. Recent studies have used new strategies to explore the prevalence, biochemical mechanisms, and evolutionary implications of these interactions—called epistasis—within proteins.
Tyler N, Starr, Joseph W, Thornton
openaire +2 more sources
, 2022 Selection for wopt transforms the reciprocal sign epistasis motif (shown in red) into the no sign epistasis motif (shown in blue) and the simple sign epistasis motif (shown in brown) with equal probability.
Malvika Srivastava (13822814) +1 more
core +1 more source
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds. [PDF]
PLoS ONE, 2012 Parallel and convergent evolution have been remarkably common observations in molecular adaptation but primarily in the context of the same genotype adapting to the same conditions.
Victoria M Pearson +2 more
doaj +1 more source
Generation mean analysis of the key earliness related traits in cowpea (Vigna unguiculata (L.) Walp)
Scientific African, 2022 The nature of gene action controlling agronomic traits enables plant breeders to execute a successful crop improvement programme. To elucidate the type of gene action governing the key earliness related traits in cowpea, seven populations of the six ...
Emmanuel Yaw Owusu +6 more
doaj +1 more source
Local incongruence: Magnitude epistasis.
, 2022 (A) The probability of retaining the type of epistasis, shown in relation to the optimal phenotype wopt. The black line shows the theoretical prediction and the dots show the results from randomly generated genotype-phenotype landscapes for different ...
Malvika Srivastava (13822814) +1 more
core +1 more source
Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
Comput. Artif. Intell., 1995 Summary: We compare two previously introduced notions of epistasis and prove that they are essentially equivalent.
van Hove, H., Verschoren, A.
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Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source