Results 51 to 60 of about 68,669 (249)

Epistasis in Monkeyflowers [PDF]

Genetics, 2005
AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
openaire   +2 more sources

Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders

Frontiers in Immunology, 2018
The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga, Rohan Ameratunga, See-Tarn Woon, Vanessa L. Bryant, Vanessa L. Bryant, Richard Steele, Charlotte Slade, Charlotte Slade, Euphemia Yee Leung, Klaus Lehnert   +9 more
doaj   +1 more source

Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The same mutation can have different effects among individuals, and one reason for this is the presence of additional mutations, a relationship known as epistasis. Epistatic effects are difficult to predict.
Robert Rauscher, G. Bampi, M. Guevara-Ferrer, Leonardo A. Santos, D. Joshi, David Mark, L. Strug, J. Rommens, M. Ballmann, E. Sorscher, Kathryn E. Oliver, Z. Ignatova   +11 more
semanticscholar   +1 more source

Global epistasis and the emergence of function in microbial consortia.

Cell
The many functions of microbial communities emerge from a complex web of interactions between organisms and their environment. This poses a significant obstacle to engineering microbial consortia, hindering our ability to harness the potential of ...
Juan Díaz-Colunga, Abigail Skwara, Jean C. C. Vila, Djordje Bajić, Álvaro Sánchez   +4 more
semanticscholar   +1 more source

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D, Gong, Lizhi Ian, Suchard, Marc A   +2 more
core   +1 more source

Epistasis not needed to explain low dN/dS

, 2012
An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on the state of other loci in the organism's genome, a phenomenon known as ...
AL Halpern, AS Kondrashov, AU Tamuri, David M. McCandlish, DM Fowler, Etienne Rajon, J da Silva, Joshua B. Plotkin, MA DePristo, MLM Salverda, MS Breen, N Rodrigue, Premal Shah, S Kryazhimskiy, SC Choi, TF Hansen, WH Li, Yang Ding, Z Yang, Z Yang   +19 more
core   +3 more sources

Evolution of robustness in digital organisms [PDF]

, 2004
We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single Imitations decreases, up until the point where a sizable fraction (up to 30% in ...
Adami, Christoph, Edlund, Jeffrey A.
core   +1 more source

Addressing epistasis in the design of protein function

Proceedings of the National Academy of Sciences of the United States of America
Mutations in protein active sites can dramatically improve function. The active site, however, is densely packed and extremely sensitive to mutations.
Rosalie Lipsh-Sokolik, S. Fleishman
semanticscholar   +1 more source

Epistasis Storyboarded

The American Biology Teacher, 2022
Through the artistic planning tool known to comic book artists and animators as storyboarding, students will embark on comic book–style adventures to plan, describe, and visualize the complex life of genes through the non-Mendelian concept of epistasis.
Caryn Babaian, Sudhir Kumar
openaire   +1 more source

Mechanistic causes of sign epistasis and its applications

Frontiers in Genetics
Mapping genetic variations to phenotypic variations poses a significant challenge, as mutations often combine unexpectedly, diverging from assumed additive effects even in the same environment.
Jinqiu Zhang, Feiyu Chen, Feiyu Chen, Xianghua Li, Xianghua Li, Xianghua Li   +5 more
doaj   +1 more source