Results 31 to 40 of about 68,669 (249)
The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross
Nature Communications, 2022 In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic effects to heritable traits, we use a double barcoding system to generate and phenotype a panel of
Takeshi Matsui +6 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
doaj +1 more source
The context-dependence of mutations: a linkage of formalisms
, 2015 Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems.
Krishna, Vinod +2 more
core +9 more sources
Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Iglesias, M. T. +3 more
openaire +4 more sources
Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks
bioRxiv, 2022 Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis confounds our understanding of how mutations impact the expression patterns of gene regulatory networks, because such nonlinearities make it difficult
F. Baier +4 more
semanticscholar +1 more source
Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
doaj +1 more source
Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing
bioRxiv, 2022 Genetic interactions occur when a variant’s phenotypic effect is altered by variation at other genomic loci. Also known as epistasis, these interactions shape the genetic architecture of complex traits and modify phenotypes across genetic backgrounds ...
Roy Moh Lik Ang +4 more
semanticscholar +1 more source
Physical Constraints on Epistasis [PDF]
Molecular Biology and Evolution, 2020 Abstract Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
Husain, Kabir, Murugan, Arvind
openaire +3 more sources
Historical contingency and entrenchment in protein evolution under purifying selection [PDF]
, 2014 The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of ...
McCandlish, David M. +2 more
core +2 more sources
Idiosyncratic epistasis leads to global fitness-correlated trends
bioRxiv, 2021 Epistasis can dramatically affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations.
Christopher W. Bakerlee +4 more
semanticscholar +1 more source