Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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Epistasis in Monkeyflowers [PDF]
Genetics, 2005 AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
openaire +2 more sources
Local incongruence: Sign epistasis.
, 2022 The probability of retaining or changing the type of epistasis in the genotype-phenotype landscape, relative to the fitness landscape, shown in relation to the optimal phenotypic value wopt.
Malvika Srivastava (13822814) +1 more
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Genetic Dissection of Wheat Heterosis Identifies Candidate Genes in Biparental and Diverse Hybrid Populations. [PDF]
Plant Biotechnol JABSTRACT Understanding how numerous heterotic quantitative trait loci (hQTL) shape heterosis and shifting from hQTL to candidate genes are central challenges. To address these challenges, we performed a systematic, genome‐wide mapping in a biparental population and a population of diverse hybrids.
Li G, Chu J, Haupt M, Jiang Y, Reif JC.
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Initial mutations direct alternative pathways of protein evolution [PDF]
, 2011 Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser +31 more
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Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations. [PDF]
PLoS ONE, 2014 OBJECTIVE AND METHODS:This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL).
Pavel Goldstein +2 more
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Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]
, 2008 Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
Jean-Luc Jannink +4 more
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Selection for cooperativity causes epistasis predominately between native contacts and enables epistasis-based structure reconstruction [PDF]
, 2021 We investigated the relationship between cooperativity and epistasis and found low cooperativity results in high epistasis between nonnative contacts, whereas high cooperatively results in epistasis mainly between native contacts.
Eccleston, RC +2 more
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BMC Bioinformatics, 2008 Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R +4 more
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Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders
Frontiers in Immunology, 2018 The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes ...
Rohan Ameratunga +9 more
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