Results 11 to 20 of about 68,669 (249)
Global epistasis emerges from a generic model of a complex trait
eLife, 2021 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M Desai
doaj +1 more source
Epistasis and evolution: recent advances and an outlook for prediction
BMC Biology, 2023 As organisms evolve, the effects of mutations change as a result of epistatic interactions with other mutations accumulated along the line of descent. This can lead to shifts in adaptability or robustness that ultimately shape subsequent evolution. Here,
Milo S. Johnson +2 more
semanticscholar +1 more source
High-order epistasis shapes evolutionary trajectories. [PDF]
PLoS Computational Biology, 2017 High-order epistasis-where the effect of a mutation is determined by interactions with two or more other mutations-makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important
Zachary R Sailer, Michael J Harms
doaj +1 more source
A network model for the correlation between epistasis and genomic complexity. [PDF]
PLoS ONE, 2008 The study of genetic interactions (epistasis) is central to the understanding of genome organization and evolution. A general correlation between epistasis and genomic complexity has been recently shown, such that in simpler genomes epistasis is ...
Rafael Sanjuán, Miguel R Nebot
doaj +1 more source
Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size
Science, 2023 Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively.
Lyndsey Aguirre +4 more
semanticscholar +1 more source
Journal of Biology, 2009 Epistasis under the classical definition describes only interactions in which one mutant phenotype is masked or suppressed in the presence of the other mutation. The population geneticist's definition includes classical epistasis, but also encompasses 'aggravating' or 'synthetic' interactions – where two mutations together yield a surprisingly ...
Roth, Fritz +2 more
openaire +3 more sources
Nested epistasis enhancer networks for robust genome regulation
Science, 2022 Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task.
Xueqiu Lin +16 more
semanticscholar +1 more source
Biomolecules, 2023 The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global epistasis effects was evaluated and compared to the accuracy of haplotype genomic prediction using 380,705 SNPs and 10-fold cross-validation studies.
Zuoxiang Liang +2 more
doaj +1 more source
Environment-independent distribution of mutational effects emerges from microscopic epistasis
bioRxiv, 2023 Predicting how new mutations alter phenotypes is difficult because mutational effects vary across genotypes and environments. Recently discovered global epistasis, where the fitness effects of mutations scale with the fitness of the background genotype ...
Sarah M. Ardell +3 more
semanticscholar +1 more source
Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1
bioRxiv, 2022 The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the ancestral Wuhan Hu-1 strain and other pre-Omicron SARS-CoV-2 variants, BA.1 has many mutations, a number of which are known to enable antibody escape 1–3 ...
Alief Moulana +9 more
semanticscholar +1 more source