Results 11 to 20 of about 37,358 (239)
PLoS Genetics, 2016 Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Kristina Crona
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Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
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Estimating directional epistasis [PDF]
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
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Epistasis: obstacle or advantage for mapping complex traits? [PDF]
PLoS ONE, 2010 Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype.
Koen J F Verhoeven +2 more
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Bulletin of the Belgian Mathematical Society - Simon Stevin, 2001 : In this note, we introduce and study the notion of normalized epistasis of a fitness function over not necessary binary alphabets, as an indicator of its CA-hardness, Fitness functions with minimal and maximal normalized epistasis are explicitly ...
Iglesias, M.T. +3 more
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The Origin of Mutational Epistasis [PDF]
European Biophysics JournalThe interconnected processes of protein folding, mutations, epistasis, and evolution have all been the subject of extensive analysis throughout the years due to their significance for structural and evolutionary biology.
Vila, Jorge A.
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Dynamic network-based epistasis analysis: Boolean examples [PDF]
Frontiers in Plant Science, 2011 In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia +5 more
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Epistasis and Adaptation on Fitness Landscapes [PDF]
, 2022 Epistasis occurs when the effect of a mutation depends on its carrier's genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious.
Bank, Claudia
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Journal of Biology, 2009 Epistasis under the classical definition describes only interactions in which one mutant phenotype is masked or suppressed in the presence of the other mutation. The population geneticist's definition includes classical epistasis, but also encompasses 'aggravating' or 'synthetic' interactions – where two mutations together yield a surprisingly ...
Roth, Fritz +2 more
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Consequences of Epistasis on Growth in an Erhualian × White Duroc Pig Cross. [PDF]
PLoS ONE, 2017 Epistasis describes an interaction between the effects of loci. We included epistasis in quantitative trait locus (QTL) mapping of growth at a series of ages in a cross of a Chinese pig breed, Erhualian, with a commercial line, White Duroc.
Lucy Crooks, Yuanmei Guo
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