Results 11 to 20 of about 27,549 (205)
PLoS Genetics, 2016 Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory.
Kristina Crona
doaj +5 more sources
Evolutionary footprint of epistasis. [PDF]
PLoS Computational Biology, 2018 Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi +2 more
doaj +4 more sources
Estimating directional epistasis [PDF]
Frontiers in Genetics, 2014 Epistasis, i.e. the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to ...
Arnaud eLE ROUZIC
doaj +3 more sources
Journal of Biology, 2009 Epistasis under the classical definition describes only interactions in which one mutant phenotype is masked or suppressed in the presence of the other mutation. The population geneticist's definition includes classical epistasis, but also encompasses 'aggravating' or 'synthetic' interactions – where two mutations together yield a surprisingly ...
Roth, Fritz +2 more
openaire +4 more sources
Physical Constraints on Epistasis [PDF]
Molecular Biology and Evolution, 2020 Abstract Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
Husain, Kabir, Murugan, Arvind
openaire +3 more sources
The impact of epistasis in the heterosis and combining ability analyses
Frontiers in Plant Science, 2023 The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
doaj +1 more source
Frontiers in Genetics, 2022 The rapid growth in genomic selection data provides unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but the methodology is lacking. Epistasis effects are interaction effects, and haplotype effects may
Yang Da +2 more
doaj +1 more source
Bulletin of the Belgian Mathematical Society - Simon Stevin, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Van Hove, H., Verschoren, A.
openaire +4 more sources
Epistasis shapes the fitness landscape of an allosteric specificity switch
Nature Communications, 2021 Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a ...
Kyle K. Nishikawa +4 more
doaj +1 more source
Epistasis in Monkeyflowers [PDF]
Genetics, 2005 AbstractEpistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on estimates for means. It thus has greater power than the
openaire +2 more sources