Results 21 to 30 of about 68,669 (249)

PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models

BMC Bioinformatics, 2022
Background Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area under active research because it could be the
Borja González-Seoane, Christian Ponte-Fernández, Jorge González-Domínguez, María J. Martín   +3 more
doaj   +1 more source

An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity

bioRxiv, 2023
Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms.
André J. Faure, Ben Lehner, V. Miró Pina, Claudia Serrano Colomé, Donate Weghorn   +4 more
semanticscholar   +1 more source

Consequences of Epistasis on Growth in an Erhualian × White Duroc Pig Cross. [PDF]

PLoS ONE, 2017
Epistasis describes an interaction between the effects of loci. We included epistasis in quantitative trait locus (QTL) mapping of growth at a series of ages in a cross of a Chinese pig breed, Erhualian, with a commercial line, White Duroc.
Lucy Crooks, Yuanmei Guo
doaj   +1 more source

Environmental modulation of global epistasis in a drug resistance fitness landscape

Nature Communications, 2023
Interactions between mutations (epistasis) can add substantial complexity to genotype-phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown that the fitness effect of a mutation can often be predicted from the fitness
Juan Díaz-Colunga, Álvaro Sánchez, C. B. Ogbunugafor   +2 more
semanticscholar   +1 more source

Evolutionary footprint of epistasis. [PDF]

PLoS Computational Biology, 2018
Variation of an inherited trait across a population cannot be explained by additive contributions of relevant genes, due to epigenetic effects and biochemical interactions (epistasis).
Gabriele Pedruzzi, Ayuna Barlukova, Igor M Rouzine   +2 more
doaj   +1 more source

Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits

bioRxiv, 2023
Epistasis is central in many domains of biology, but it has not yet proven useful for complex traits. This is partly because complex trait epistasis involves polygenic interactions that are poorly captured in current models.
David Tang, Jerome Freudenberg, Andy Dahl   +2 more
semanticscholar   +1 more source

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

bioRxiv, 2022
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutralizing receptor ...
Leander Witte, Viren A. Baharani, F. Schmidt, Zijun Wang, A. Cho, Raphael Raspe, Camila Guzmán-Cardozo, Frauke Muecksch, Marie Canis, D. Park, C. Gaebler, M. Caskey, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +14 more
semanticscholar   +1 more source

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

mBio, 2022
Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide.
N. Rochman, Guilhem Faure, Y. Wolf, L. Freddolino, Feng Zhang, E. Koonin   +5 more
semanticscholar   +1 more source

The impact of epistasis in the heterosis and combining ability analyses

Frontiers in Plant Science, 2023
The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
doaj   +1 more source

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source