Results 41 to 50 of about 68,669 (249)
Hidden epistastic interactions can favour the evolution of sex and recombination. [PDF]
PLoS ONE, 2012 Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness.
Joel R Peck, David Waxman, John J Welch
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Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Scientific Reports, 2022 Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations.
Yanbing Wang +9 more
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Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction
Alzheimer's Research & Therapy, 2021 Background Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer’s disease (AD).
Hui Wang +4 more
semanticscholar +1 more source
Global epistasis emerges from a generic model of a complex trait
bioRxiv, 2020 Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread “microscopic” epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between ...
Gautam Reddy, Michael M. Desai
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Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations. [PDF]
PLoS ONE, 2014 OBJECTIVE AND METHODS:This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL).
Pavel Goldstein +2 more
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Dynamic network-based epistasis analysis: Boolean examples
Frontiers in Plant Science, 2011 In this review we focus on how the hierarchical and single-path assumptions of epistasis analysis can bias the topologies of gene interactions infered. This has been acknowledged in several previous papers and reviews, but here we emphasize the critical ...
Eugenio eAzpeitia +5 more
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Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
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TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021 Key message Including additive and additive-by-additive epistasis in a NOIA parametrization did not yield orthogonal partitioning of genetic variances, nevertheless, it improved predictive ability in a leave-one-out cross-validation for wheat grain yield.
M. Raffo +7 more
semanticscholar +1 more source
BMC Bioinformatics, 2008 Background Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect.
Garbe John R +4 more
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A model and test for coordinated polygenic epistasis in complex traits
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Systems-level interactions across physiological pathways, cell types, and tissues are core biological elements widely studied across diverse fields including evolution, systems biology, and model-organism genetics.
B. Sheppard +5 more
semanticscholar +1 more source