Results 101 to 110 of about 55,446 (204)
Complexity of evolutionary equilibria in static fitness landscapes [PDF]
, 2013 A fitness landscape is a genetic space -- with two genotypes adjacent if they differ in a single locus -- and a fitness function. Evolutionary dynamics produce a flow on this landscape from lower fitness to higher; reaching equilibrium only if a local ...
Kaznatcheev, Artem
core
Exploiting barley landraces to reintroduce lost genetic diversity: Resistance to net form net blotch
Crop Science, Volume 65, Issue 3, May/June 2025.Abstract Centuries of barley (Hordeum vulgare) domestication and selection has resulted in reduced genetic diversity in modern cultivars, limiting breeder's options to select desirable traits. Barley landraces, heirloom varieties, and wild relatives are substantially more variable and can be exploited to reintroduce favorable genes and alleles.
Nola K. D'Souza +7 more
wiley +1 more source
Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model
, 2014 The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume +3 more
core +1 more source
Physical constraints on epistasis [PDF]
arXiv, 2019 Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis.
arxiv
Robustness and epistasis in mutation-selection models
, 2009 We investigate the fitness advantage associated with the robustness of a phenotype against deleterious mutations using deterministic mutation-selection models of quasispecies type equipped with a mesa shaped fitness landscape.
Andrea Wolff +11 more
core +2 more sources
Aging Cell, Volume 24, Issue 5, May 2025.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
EpiGEN: an epistasis simulation pipeline
Bioinformatics, 2020 Abstract Summary Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only ...
Blumenthal +11 more
openaire +3 more sources
Multidimensional Epistasis and the Advantage of Sex
, 2005 Kondrashov and Kondrashov (2001) suggest that there is usually a disadvantage for sex in systems with multidimensional epistasis. They define systems of 'unidimensional epistasis' to be those where the fitness of a genotype is a function of the number of
Wakeley, John, Watson, Richard A.
core
Epistasis and Shapes of Fitness Landscapes [PDF]
, 2006 The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions.
Beerenwinkel, Niko +2 more
core +4 more sources
Repeatability of evolution on epistatic landscapes
, 2015 Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
core +1 more source