Results 101 to 110 of about 38,773 (257)

Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis

BioData Mining
Purpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all
Sandra Batista, Vered Senderovich Madar, Philip J. Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S. Chitre, Abraham A. Palmer, Jason H. Moore   +8 more
doaj   +1 more source

Association mapping for epistasis and environmental interaction of yield traits in 323 cotton cultivars under 9 different environments. [PDF]

PLoS ONE, 2014
Improving yield is a major objective for cotton breeding schemes, and lint yield and its three component traits (boll number, boll weight and lint percentage) are complex traits controlled by multiple genes and various environments.
Yinhua Jia, Xiwei Sun, Junling Sun, Zhaoe Pan, Xiwen Wang, Shoupu He, Songhua Xiao, Weijun Shi, Zhongli Zhou, Baoyin Pang, Liru Wang, Jianguang Liu, Jun Ma, Xiongming Du, Jun Zhu   +14 more
doaj   +1 more source

Genetic mapping and haplotype analysis identify novel candidate genes for high night temperature tolerance in winter wheat

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract A diverse panel of 320 winter wheat (Triticum aestivum L.) genotypes was evaluated for yield‐related parameters under control and high night‐time temperature (HNT) stress using custom‐designed, movable field‐based heat tents over 2 years. Genome‐wide association mapping identified several significant single nucleotide polymorphisms (SNPs ...
Dinesh Kumar Saini, Nathan T. Hein, Impa Somayanda, Raju Bheemanahalli, Troy Ostmeyer, S. V. Krishna Jagadish   +5 more
wiley   +1 more source

Mutation and Epistasis in Influenza Virus Evolution

Viruses, 2018
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains.
Daniel M. Lyons, A. Lauring
semanticscholar   +1 more source

Ensemble epistasis: thermodynamic origins of nonadditivity between mutations

bioRxiv, 2020
Non-additivity between mutations—epistasis—profoundly shapes evolution. It can be difficult to understand its mechanistic origins. Here we show that “ensemble epistasis” is likely a universal feature of macromolecules. Using a simple analytical model, we
Anneliese J. Morrison, Daria R. Wonderlick, M. Harms   +2 more
semanticscholar   +1 more source

Trait mapping differentiates loci influencing spike and flag leaf glaucousness in wheat

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract The bluish‐white appearance of some plants, known as glaucousness, results from the scattering effect of visible light due to plant surface waxes. This adaptive trait can contribute to tolerance of abiotic stresses in wheat (Triticum aestivum L.) such as drought, solar radiation, and heat.
Daniela Miller, Luis Rivera‐Burgos, Mohammed Guedira, Noah DeWitt, Brian Ward, J. Paul Murphy, Amanda M. Hulse‐Kemp, Gina Brown‐Guedira   +7 more
wiley   +1 more source

A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non‐ordered process driven by chance and sharp observation.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Performance analysis of novel methods for detecting epistasis

BMC Bioinformatics, 2011
Background Epistasis is recognized fundamentally important for understanding the mechanism of disease-causing genetic variation. Though many novel methods for detecting epistasis have been proposed, few studies focus on their comparison.
Shang Junliang, Zhang Junying, Sun Yan, Liu Dan, Ye Daojun, Yin Yaling   +5 more
doaj   +1 more source

Polygenic Scores of Executive Function Provide Limited Support for Genetic Confounding With Socio‐Economic Measures

Genes, Brain and Behavior, Volume 24, Issue 4, August 2025.
While there is good reason to believe EF research has been subject to genetic confounding, the specialized samples required to test for it can be impractical for researchers. We tested one proposed alternative genetic control, polygenic scores, finding that they produced modest evidence for genetic confounding inconsistent with other literature ...
Lucas C. Perry, Nicolas Chevalier, Michelle Luciano   +2 more
wiley   +1 more source

Selection on genome‐wide gene expression plasticity of rice in wet and dry field environments

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Gene expression can be highly plastic in response to environmental variation. However, we know little about how expression plasticity is shaped by natural selection and evolves in wild and domesticated species. We used genotypic selection analysis to characterize selection on drought‐induced plasticity of over 7,500 leaf transcripts of 118 ...
Elena Hamann, Simon C. Groen, Taryn S. Dunivant, Irina Ćalić, Colleen Cochran, Rachel Konshok, Michael D. Purugganan, Steven J. Franks   +7 more
wiley   +1 more source