Results 101 to 110 of about 71,733 (264)
Privacy-preserving decision tree for epistasis detection
Cybersecurity, 2019 The interaction between gene loci, namely epistasis, is a widespread biological genetic phenomenon. In genome-wide association studies(GWAS), epistasis detection of complex diseases is a major challenge. Although many approaches using statistics, machine
Qingfeng Chen, Xu Zhang, Ruchang Zhang
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Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. [PDF]
, 2016 Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive.
Bloom, Joshua S +4 more
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Inferring the shape of global epistasis
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance How does an organism’s genetic sequence govern its measurable characteristics? New technologies provide libraries of randomized sequences to study this relationship in unprecedented detail for proteins and other molecules.
Jakub Otwinowski +2 more
semanticscholar +1 more source
Phenotype Prediction Under Epistasis
, 2021 Reliable methods of phenotype prediction from genomic data play an increasingly important role in many areas of plant and animal breeding. Thus, developing methods that enhance prediction accuracy is of major interest. Here, we provide three methods for this purpose: (1) Genomic Best Linear Unbiased Prediction (GBLUP) as a model just accounting for ...
Vojgani, Elaheh +3 more
openaire +3 more sources
Repeatability of evolution on epistatic landscapes
, 2015 Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
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BioData MiningPurpose Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all
Sandra Batista +8 more
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Multidimensional Epistasis and the Advantage of Sex
, 2005 Kondrashov and Kondrashov (2001) suggest that there is usually a disadvantage for sex in systems with multidimensional epistasis. They define systems of 'unidimensional epistasis' to be those where the fitness of a genotype is a function of the number of
Wakeley, John, Watson, Richard A.
core
mBio, 2018 Mosaic interspecifically acquired alleles of the multiple transferable resistance (mtr) efflux pump operon correlate with increased resistance to azithromycin in Neisseria gonorrhoeae in epidemiological studies.
Crista B. Wadsworth +3 more
semanticscholar +1 more source
Performance analysis of novel methods for detecting epistasis
BMC Bioinformatics, 2011 Background Epistasis is recognized fundamentally important for understanding the mechanism of disease-causing genetic variation. Though many novel methods for detecting epistasis have been proposed, few studies focus on their comparison.
Shang Junliang +5 more
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Mutation supply and the repeatability of selection for antibiotic resistance
, 2017 Whether evolution can be predicted is a key question in evolutionary biology. Here we set out to better understand the repeatability of evolution. We explored experimentally the effect of mutation supply and the strength of selective pressure on the ...
de Visser, J. Arjan G. M. +4 more
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