Results 101 to 110 of about 59,992 (241)
PLANTS, PEOPLE, PLANET, Volume 7, Issue 6, Page 1657-1673, November 2025.Plant breeding is a critical tool for increasing the productivity, climate resilience, and sustainability of agriculture, but current phenotyping methods are a bottleneck due to the amount of human labor involved. Here, we demonstrate high‐throughput phenotyping with an unmanned aerial vehicle (UAV) to analyze the season‐long flowering pattern in ...
Jeevan Adhikari +5 more
wiley +1 more source
Multidimensional Epistasis and the Advantage of Sex
, 2005 Kondrashov and Kondrashov (2001) suggest that there is usually a disadvantage for sex in systems with multidimensional epistasis. They define systems of 'unidimensional epistasis' to be those where the fitness of a genotype is a function of the number of
Wakeley, John, Watson, Richard A.
core
Directed evolution of a beta‐lactamase samples a wide variety of conformational states
Protein Science, Volume 34, Issue 11, November 2025.Abstract In directed evolution, enzyme activity is improved in successive generations of laboratory evolution, which can be described by a simple stepwise climb toward a peak in the fitness landscape. In a naive model of evolution, it can be assumed that each enzyme variant along this path is in a single, well‐defined state that differs slightly from ...
Jing Sun +4 more
wiley +1 more source
Repeatability of evolution on epistatic landscapes
, 2015 Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes.
Bauer, Benedikt, Gokhale, Chaitanya S.
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Universality classes of interaction structures for NK fitness landscapes
, 2018 Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca +3 more
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Performance analysis of novel methods for detecting epistasis
BMC Bioinformatics, 2011 Background Epistasis is recognized fundamentally important for understanding the mechanism of disease-causing genetic variation. Though many novel methods for detecting epistasis have been proposed, few studies focus on their comparison.
Shang Junliang +5 more
doaj +1 more source
COMPUTING AND INFORMATICS, 2012 Normalized epistasis measures links between separate bits in binary strings. It is used in optimization. Unitarian functions (fitness functions \(f\) whose values depends only upon the number of ones rep. zeros in the optimized binary string) with extreme epistasis are theoretically studied. The epistasis of a binary string \(s = s_{l - 1} \cdots s_0\)
M. T. Iglesias +3 more
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Journal of Animal Breeding and Genetics, Volume 142, Issue 6, Page 675-684, November 2025.ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior to the estimation of genetic parameters. However, the impact of different transformations on genetic parameter estimates depends on the dataset at hand.
Evan Hartono +5 more
wiley +1 more source
Life, 2018 The domino theory of gene loss states that when some particular gene loses its function and cripples a cellular function, selection will relax in all functionally related genes, which may allow for the non-functionalization and loss of these genes.
David J. Martínez-Cano +3 more
doaj +1 more source
Reconstructability Analysis of Epistasis
Annals of Human Genetics, 2010 The literature on epistasis describes various methods to detect epistatic interactions and to classify different types of epistasis. Reconstructability analysis (RA) has recently been used to detect epistasis in genomic data. This paper shows that RA offers a classification of types of epistasis at three levels of resolution (variable-based models ...
openaire +5 more sources