A fundamental and theoretical framework for mutation interactions and epistasis. [PDF]
Giacoletto CJ+3 more
europepmc +1 more source
MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data. [PDF]
Faure AJ, Lehner B.
europepmc +1 more source
The Role of Pleiotropy and Epistasis on Evolvability and Robustness in a Two-Peak Fitness Landscape. [PDF]
Mehra P, Hintze A.
europepmc +1 more source
Global regulators enable bacterial adaptation to a phenotypic trade-off. [PDF]
Deyell M+4 more
europepmc +1 more source
Higher-order epistasis within Pol II trigger loop haplotypes. [PDF]
Duan B+4 more
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Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification [PDF]
Bielak, Lawrence F.+7 more
core +1 more source
Novel Regulators and Their Epistatic Networks in Arabidopsis' Defence Responses to Alternaria alternata Infection. [PDF]
Zeng Q+8 more
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Optimizing enzyme thermostability by combining multiple mutations using protein language model. [PDF]
Bian J, Tan P, Nie T, Hong L, Yang GY.
europepmc +1 more source
DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance. [PDF]
Chen J, Chitrakar R, Baugh LR.
europepmc +1 more source