Hook1 inhibits malignancy and epithelial–mesenchymal transition in hepatocellular carcinoma
Tumor Biology, 2017 Hook1 is a member of the hook family of coiled-coil proteins, which is recently found to be associated with malignant tumors. However, its biological function in hepatocellular carcinoma is yet unknown.
Xu Sun +13 more
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Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
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Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]
, 2016 Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A. +1 more
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Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis
Journal of RhinologyChronic rhinosinusitis (CRS) is characterized by prolonged inflammation of the nasal and paranasal sinus mucosa lasting over 12 weeks. CRS is divided into two main types based on the presence of nasal polyps: CRS without nasal polyps and CRS with nasal polyps.
Taewoong Choi +4 more
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Epithelial–mesenchymal transition and gastric cancer stem cell
Tumor Biology, 2017 Gastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity.
Pu Xia, Xiao-Yan Xu
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The mesenchymal transcription factor SNAI-1 instructs human liver specification
Stem Cell Research, 2016 Epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET) are processes required for embryo organogenesis. Liver develops from the epithelial foregut endoderm from which the liver progenitors, hepatoblasts, are specified ...
Orit Goldman +3 more
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Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Frontiers in Oncology, 2015 Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is Epithelial-to-Mesenchymal Transition (EMT) and its reverse Mesenchymal-to ...
Mohit Kumar eJolly +7 more
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Epithelial–Mesenchymal Transition (EMT) : its theranostic role in cancer progression and metastasis [PDF]
, 2014 Epithelial-mesenchymal transition (EMT) is a process by which a fully differentiated epithelial cell attains mesenchymal traits and capabilities such as motility and invasiveness. There are three types.
Baldacchino, Alexandra, Grech, Alfred
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Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition [PDF]
, 2004 Jiří Zavadil +3 more
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Molecular Therapy: Nucleic Acids, 2019 Lung epithelial-mesenchymal transition (EMT) plays an important role in silicosis fibrosis. The reverse process of EMT is mesenchymal-epithelial transition (MET), which is viewed as an anti-EMT therapy and is a good target toward fibrosis.
Jingping Sun +9 more
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