Results 21 to 30 of about 2,769,274 (304)

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
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The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy [PDF]

, 2011
Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of tubulointerstitial fibrosis is epithelial-to-mesenchymal transition ...
Hills, Claire E., Paul E. Squires, Claire E. Hills, Squires, Paul E.   +3 more
core   +1 more source

Epithelial-mesenchymal transition [PDF]

Journal of Cell Science, 2005
The epithelial-mesenchymal transition (EMT) is an orchestrated series of events in which cell-cell and cell-extracellular matrix (ECM) interactions are altered to release epithelial cells from the surrounding tissue, the cytoskeleton is reorganized to confer the ability to move through a three-
openaire   +2 more sources

Metabolic Plasticity and Epithelial-Mesenchymal Transition [PDF]

Journal of Clinical Medicine, 2019
A major transcriptional and phenotypic reprogramming event during development is the establishment of the mesodermal layer from the ectoderm through epithelial-mesenchymal transition (EMT). EMT is employed in subsequent developmental events, and also in many physiological and pathological processes, such as the dissemination of cancer cells through ...
Timothy M. Thomson, Cristina Balcells, Marta Cascante   +2 more
openaire   +4 more sources

Epithelial–Mesenchymal Transition in Ovarian Carcinoma [PDF]

Frontiers in Oncology, 2012
Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression ...
Davidson, Ben, Tropé, Claes G., Reich, Reuven   +2 more
openaire   +3 more sources

HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]

, 2010
Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P., Michael P. Ryan, Slattery, Craig, Tara McMorrow, Nolan, Stephen, Ronan Feighery, Craig Slattery, Feighery, Ronan, Stephen Nolan, Julie Lynch, Lynch, Julie, McMorrow, Tara   +11 more
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Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma [PDF]

Future Oncology, 2009
The transition of epithelial cells to a mesenchymal phenotype is of paramount relevance for embryonic development and adult wound healing. During the past decade, the epithelial-mesenchymal transition (EMT) has been increasingly recognized to occur during the progression of various carcinomas such as hepatocellular carcinoma (HCC).
van Zijl, Franziska, Zulehner, Gudrun, Petz, Michaela, Schneller, Doris, Kornauth, Christoph, Hau, Mara, Machat, Georg, Grubinger, Markus, Huber, Heidemarie, Mikulits, Wolfgang   +9 more
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An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]

, 2011
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan, Caldwell Helen, Dubois-Marshall, Sylvie, Sylvie Dubois-Marshall, Helen Caldwell, Sims, Andrew H., Sims Andrew H., Elad Katz, Katz Elad, Elad Katz, Meehan Richard R., Meehan, Richard R, Richard R Meehan, Gautier Philippe, David J. Harrison, Richard R, Harrison David J., Gautier, Philippe, Dubois-Marshall Sylvie, Sims, Andrew H, Philippe Gautier, Harrison, David J, David J Harrison, Katz, Elad, Andrew H. Sims, Meehan, Richard R., Andrew H Sims, Caldwell, Helen, Harrison, David J.   +28 more
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Targeting epithelial–mesenchymal transition [PDF]

Journal of Molecular Medicine, 2015
The epithelial–mesenchymal transition (EMT) is a process in which epithelial cells dedifferentiate to become mesenchymal cells [1–3]. The process requires them to lose their cell polarity, to relinquish their cell–cell adhesion, and to gain migratory and invasive properties.
openaire   +2 more sources

Human Cancer Cells Express Slug-based Epithelial-Mesenchymal Transition Gene Signature Obtained in Vivo [PDF]

, 2011
The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).
Rumjantseva Viktoria, Cheng Weiyi, Viktoria Rumjantseva, Kandel Jessica J, Jessica J Kandel, Yamashiro, Darrell, Jianzhong Huang, Peter D. Canoll, Huang, Jianzhong, Dimitris Anastassiou, Anastassiou Dimitris, Darrell J Yamashiro, Yamashiro Darrell J, Canoll Peter D, Canoll, Peter D., Kandel, Jessica J., Wei-yi Cheng, Rumjantseva, Viktoria, Huang Jianzhong, Jessica J. Kandel, Cheng, Weiyi, Darrell J. Yamashiro, Weiyi Cheng, Anastassiou, Dimitris, Peter D Canoll   +24 more
core   +2 more sources