Results 31 to 40 of about 2,769,274 (304)

Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition [PDF]

, 2013
Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Adam I. Marcus, Songli Xu (457629), Anapatricia Garcia (457628), Paula M. Vertino (457631), Klymkowsky, Michael, Doris R Powell, Marcus Adam I., Vertino, PM, Anapatricia Garcia, Shivendra Singh (457632), Singh Shivendra, Yang, Zhen, Doris R. Powell (457630), Paula M Vertino, Garcia Anapatricia, Vertino Paula M., Singh, Shivendra, Paula M. Vertino, Adam I Marcus, Marcus, Adam I., Garcia, A, Powell, DR, Shivendra Singh, Singh, S, Zhen Yang (107412), Powell, Doris R., Zhen Yang, Yang, Z, Yang Zhen, Vertino, Paula M., Songli Xu, Xu, S, Garcia, Anapatricia, Xu, Songli, Doris R. Powell, Zhen Yang, Adam I. Marcus (457633), Powell Doris R., Marcus, AI, Xu Songli   +39 more
core   +2 more sources

MicroRNAs regulate the epithelial–mesenchymal transition and influence breast cancer invasion and metastasis

Tumor Biology, 2017
MicroRNAs are small RNA molecules that play a major role in the post-transcriptional regulation of genes and influence the development, differentiation, proliferation, and apoptosis of cells and the development and progression of tumors.
Min Zhao, Lin Ang, Jin Huang, Jin Wang
doaj   +1 more source

Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds

Tumor Biology, 2017
In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. In vivo, features of epithelial–mesenchymal transition have been associated with tumor
Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert   +16 more
doaj   +1 more source

p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. [PDF]

PLoS ONE, 2013
The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT.
Jan Roger Olsen, Anne Margrete Oyan, Kari Rostad, Margrete R Hellem, Jie Liu, Lisha Li, David R Micklem, Hallvard Haugen, James B Lorens, Varda Rotter, Xi-Song Ke, Biaoyang Lin, Karl-Henning Kalland   +12 more
doaj   +1 more source

The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells

Tumor Biology, 2017
Epithelial–mesenchymal transition is a crucial event for metastasis and could be mediated by several pathways such as phosphoinositide 3-kinase/Akt, mitogen-activated protein kinases, as well as many epigenetic regulators.
Hakan Kucuksayan, Hakan Akca
doaj   +1 more source

HR+HER2− breast cancers with growth factor receptor–mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells

Tumor Biology, 2017
Despite an overall good prognosis, a significant proportion of patients with hormone receptor positive human epidermal growth factor receptor 2 negative breast cancers develop distant metastases.
Krisha Desai, Radhika Aiyappa, Jyothi S Prabhu, Madhumathy G Nair, Patrick Varun Lawrence, Aruna Korlimarla, Anupama CE, Annie Alexander, Rohini S Kaluve, Suraj Manjunath, Marjorrie Correa, BS Srinath, Shekhar Patil, Anjali Kalamdani, MSN Prasad, TS Sridhar   +15 more
doaj   +1 more source

β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells

Respiratory Research, 2017
Background Epithelial-mesenchymal transition is currently recognized as an important mechanism for the increased number of myofibroblasts in cancer and fibrotic diseases.
Keigo Kainuma, Tetsu Kobayashi, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Hajime Fujimoto, Yu Kuwabara, Koa Hosoki, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza   +11 more
doaj   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Königshoff, M., Melanie Königshoff, Königshoff, Melanie   +2 more
core   +1 more source

Tetraspanin in oncogenic epithelial-mesenchymal transition [PDF]

Journal of Clinical Investigation, 2008
Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al.
Muschel, Ruth J., Gal, Annamaria
openaire   +3 more sources

Communication Between Epithelial–Mesenchymal Plasticity and Cancer Stem Cells: New Insights Into Cancer Progression

Frontiers in Oncology, 2021
The epithelial–mesenchymal transition (EMT) is closely associated with the acquisition of aggressive traits by carcinoma cells and is considered responsible for metastasis, relapse, and chemoresistance.
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Hong Zou, Li Feng, Mingqing Xu, Mingqing Xu   +7 more
doaj   +1 more source