Results 31 to 40 of about 208,684 (264)

Tetraspanin in oncogenic epithelial-mesenchymal transition [PDF]

Journal of Clinical Investigation, 2008
Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al.
Muschel, Ruth J., Gal, Annamaria
openaire   +3 more sources

Cancer spreading patterns based on epithelial-mesenchymal plasticity

Frontiers in Cell and Developmental Biology
Introduction: Metastasis is a major cause of cancer-related deaths, underscoring the necessity to discern the rules and patterns of cancer cell spreading. Epithelial-mesenchymal plasticity contributes to cancer aggressiveness and metastasis.
Rui Wang, Zhaopeng Yan
doaj   +1 more source

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]

PLoS ONE, 2016
BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist, Seema Somji, Jane R Dunlevy, Scott H Garrett, Xu Dong Zhou, Andrea Slusser-Nore, Donald A Sens   +6 more
doaj   +1 more source

Communication Between Epithelial–Mesenchymal Plasticity and Cancer Stem Cells: New Insights Into Cancer Progression

Frontiers in Oncology, 2021
The epithelial–mesenchymal transition (EMT) is closely associated with the acquisition of aggressive traits by carcinoma cells and is considered responsible for metastasis, relapse, and chemoresistance.
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Hong Zou, Li Feng, Mingqing Xu, Mingqing Xu   +7 more
doaj   +1 more source

MicroRNAs as regulators of epithelial-mesenchymal transition [PDF]

Cell Cycle, 2008
Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis.
Gregory, P., Bracken, C., Bert, A., Goodall, G.   +3 more
openaire   +3 more sources

miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.

PLoS ONE, 2014
Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers.
Yuanming Shen, Jiansong Zhou, Yang Li, Feng Ye, Xiaoyun Wan, Weiguo Lu, Xing Xie, Xiaodong Cheng   +7 more
doaj   +1 more source

Progress in Epithelial-Mesenchymal Transition Research [PDF]

Cells Tissues Organs, 2013
Cells Tissues Organs [Thompson et al., 2011]. The TEMTIA meetings were inaugurated in 2003 explicitly to bridge across all these disciplines, so that experts in the various fields – who rarely attended the same conferences – could mutually benefit.
Donald F, Newgreen, Erik W, Thompson
openaire   +2 more sources

Quantifying the Rate, Degree, and Heterogeneity of Morphological Change during an Epithelial to Mesenchymal Transition Using Digital Holographic Cytometry

Applied Sciences, 2020
Cells in complex organisms can transition between epithelial and mesenchymal phenotypes during both normal and malignant physiological events. These two phenotypes are not binary, but rather describe a spectrum of cell states along an axis.
Sofia Kamlund, Birgit Janicke, Kersti Alm, Robert L. Judson-Torres, Stina Oredsson   +4 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Epigenetic regulation of epithelial–mesenchymal transition [PDF]

Cellular and Molecular Life Sciences, 2016
Epithelial-mesenchymal transition (EMT) is an essential process for morphogenesis and organ development which reversibly enables polarized epithelial cells to lose their epithelial characteristics and to acquire mesenchymal properties. It is now evident that the aberrant activation of EMT is also a critical mechanism to endow epithelial cancer cells ...
Lidong Sun, Jia Fang
openaire   +2 more sources