Results 61 to 70 of about 324,947 (241)
Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]
PLoS ONE, 2016 BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist +6 more
doaj +1 more source
Frontiers in Oncology, 2021 The epithelial–mesenchymal transition (EMT) is closely associated with the acquisition of aggressive traits by carcinoma cells and is considered responsible for metastasis, relapse, and chemoresistance.
Xiaobo Zheng +7 more
doaj +1 more source
TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]
, 2010 Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core +1 more source
Epithelial–mesenchymal transition in tumor metastasis [PDF]
Molecular Oncology, 2016 The epithelial–mesenchymal transition (EMT) is a developmental program that enables stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells reactivate EMT to acquire molecular alterations that enable the partial loss of epithelial features and partial gain of a mesenchymal phenotype.
Jing Yang, Kay T. Yeung
openaire +3 more sources
Cancer spreading patterns based on epithelial-mesenchymal plasticity
Frontiers in Cell and Developmental BiologyIntroduction: Metastasis is a major cause of cancer-related deaths, underscoring the necessity to discern the rules and patterns of cancer cell spreading. Epithelial-mesenchymal plasticity contributes to cancer aggressiveness and metastasis.
Rui Wang, Zhaopeng Yan
doaj +1 more source
EMT/MET at the crossroad of stemness, regeneration and oncogenesis. The Ying-Yang equilibrium recapitulated in cell spheroids [PDF]
, 2017 The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression.
Angelini, Francesco +7 more
core +2 more sources
MicroRNAs as regulators of epithelial-mesenchymal transition [PDF]
Cell Cycle, 2008 Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis.
Gregory, P. +3 more
openaire +4 more sources
Applied Sciences, 2020 Cells in complex organisms can transition between epithelial and mesenchymal phenotypes during both normal and malignant physiological events. These two phenotypes are not binary, but rather describe a spectrum of cell states along an axis.
Sofia Kamlund +4 more
doaj +1 more source
New insights into the crossroads between EMT and stemness in the context of cancer [PDF]
, 2016 The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in
Fabregat Romero, Isabel +2 more
core +1 more source
Epithelial–mesenchymal transition in malignant mesothelioma [PDF]
Modern Pathology, 2012 Epithelial-mesenchymal transition is a physiopathological process by which epithelial cells acquire mesenchymal shape and properties. Malignant mesothelioma is histologically characterized by the concomitant presence of epithelioid and sarcomatoid features, the latter being associated to worse prognosis, thus suggesting a role of epithelial-mesenchymal
FASSINA, AMBROGIO +6 more
openaire +4 more sources