Results 91 to 100 of about 2,478,278 (345)

Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. [PDF]

, 2009
Mucosal epithelial cells are the primary targets for many common viral pathogens of cats. Viral infection of epithelia can damage or disrupt the epithelial barrier that protects underlying tissues.
Heymer, Anna, Liu, Hongwei, Millon, Lee, Ossiboff, Robert J, Parker, John SL, Pesavento, Patricia, Stucker, Karla M, van der List, Deborah, Wood, Jason   +8 more
core  

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin

Scientific Reports
Oral lichen planus (OLP) is a chronic inflammatory disorder featured with T lymphocytes infiltration and epithelial basement membrane breakdown. Although matrix metalloproteinase-12 (MMP12) is reported to be involved in the pathogenesis of oral diseases ...
Zhouqiao Xie, Xiangyu Wang, Xiuyun Ren, Xuejun Ge   +3 more
doaj   +1 more source

Extra-adrenal glucocorticoid synthesis at epithelial barriers [PDF]

Genes & Immunity, 2019
Epithelial barriers play an important role in the exchange of nutrients, gases, and other signals between our body and the outside world. However, they protect it also from invasion by potential pathogens. Defective epithelial barriers and associated overshooting immune responses are the basis of many different inflammatory disorders of the skin, the ...
Phan, Truong San, Merk, Verena M., Brunner, Thomas   +2 more
openaire   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]

, 2019
Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R., Awad, W. A., Hess, C., Hess, M., Khayal, B.   +4 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Salmonella Effector SpvB Disrupts Intestinal Epithelial Barrier Integrity for Bacterial Translocation

Frontiers in Cellular and Infection Microbiology, 2020
Salmonella are common enteric bacterial pathogens that infect both humans and animals. Intestinal epithelial barrier, formed by a single layer of epithelial cells and apical junctional complex (AJC), plays a crucial role in host defense against enteric ...
Lanqing Sun, Sidi Yang, Qifeng Deng, Kedi Dong, Yuanyuan Li, Shuyan Wu, Rui Huang   +6 more
semanticscholar   +1 more source