Results 101 to 110 of about 2,478,278 (345)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intestinal epithelial barrier and neuromuscular compartment in health and disease

World Journal of Gastroenterology, 2020
A number of digestive and extra-digestive disorders, including inflammatory bowel diseases, irritable bowel syndrome, intestinal infections, metabolic syndrome and neuropsychiatric disorders, share a set of clinical features at gastrointestinal level ...
V. D’Antongiovanni, C. Pellegrini, M. Fornai, R. Colucci, C. Blandizzi, L. Antonioli, N. Bernardini   +6 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Role of Defective Epithelial Barriers in Allergic Lung Disease and Asthma Development

Journal of Asthma and Allergy, 2022
Nazek Noureddine,1– 3 Maciej Chalubinski,4 Paulina Wawrzyniak1,2 1Division of Clinical Chemistry and Biochemistry, University Children’s Hospital Zurich, Zurich, Switzerland; 2Children’s Research Center, University Children’s Hospital Zurich, Zurich ...
Noureddine N, Chalubinski M, Wawrzyniak P   +2 more
doaj  

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

Stem Cell Research, 2019
The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the digestive tract, including inflammatory bowel diseases and colorectal cancer.
Marco Bardenbacher, Barbara Ruder, Nathalie Britzen-Laurent, Benjamin Schmid, Maximilian Waldner, Elisabeth Naschberger, Michael Scharl, Werner Müller, Claudia Günther, Christoph Becker, Michael Stürzl, Philipp Tripal   +11 more
doaj   +1 more source

Comparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

Clinical and Translational Allergy, 2021
Background Several studies have shown a correlation between an altered metabolome and respiratory allergies. The epithelial barrier hypothesis proposes that an epithelial barrier dysfunction can result in allergic diseases development.
Juan Carlos López‐Rodríguez, Juan Rodríguez‐Coira, Sara Benedé, Coral Barbas, Domingo Barber, María Teresa Villalba, María Marta Escribese, Alma Villaseñor, Eva Batanero   +8 more
doaj   +1 more source

Adenosine in Intestinal Epithelial Barrier Function

Cells
At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier. In intestinal disorders, such as inflammatory bowel disease (IBD), barrier function is compromised, which results in rampant ...
Mariya Stepanova, Carol M. Aherne
openaire   +3 more sources

Neutrophils Compromise Retinal Pigment Epithelial Barrier Integrity [PDF]

Journal of Biomedicine and Biotechnology, 2010
We hypothesized that neutrophils and their secreted factors mediate breakdown of the integrity of the outer blood-retina-barrier by degrading the apical tight junctions of the retinal pigment epithelium (RPE). The effect of activated neutrophils or neutrophil cell lysate on apparent permeability of bovine RPE-Choroid explants was evaluated by measuring[
Zhou, Jiehao, He, Shikun, Zhang, Ning, Spee, Christine, Zhou, Peng, Ryan, Stephen J., Kannan, Ram, Hinton, David R.   +7 more
openaire   +2 more sources