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Environmental factors in epithelial barrier dysfunction [PDF]
Journal of Allergy and Clinical Immunology, 2020 The main interfaces controlling and attempting to homeostatically balance communications between the host and the environment are the epithelial barriers of the skin, gastrointestinal system, and airways. The epithelial barrier constitutes the first line of physical, chemical, and immunologic defenses and provides a protective wall against ...
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The maintenance of an oral epithelial barrier
Life Sciences, 2019Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to
Sha-Sha Wang, Ya-Ling Tang, Xin Pang
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The epithelial barrier theory and its associated diseases [PDF]
Allergy: European Journal of Allergy and Clinical ImmunologyThe prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory
Na Sun +2 more
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Epithelial Barriers in Intestinal Inflammation
Antioxidants & Redox Signaling, 2011The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John +2 more
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Epithelial Barriers in Homeostasis and Disease
Annual Review of Pathology: Mechanisms of Disease, 2010Epithelia form barriers that are essential to life. This is particularly true in the intestine, where the epithelial barrier supports nutrient and water transport while preventing microbial contamination of the interstitial tissues. Along with plasma membranes, the intercellular tight junction is the primary cellular determinant of epithelial barrier ...
Amanda M, Marchiando +2 more
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The epithelial barrier and airway responsiveness
Canadian Journal of Physiology and Pharmacology, 1995Epithelial injury and bronchial hyperresponsiveness are commonly associated with airway disease, and are widely considered to occur as the result of inflammatory changes in the airway wall. Mechanistically, the airway epithelium may influence the sensitivity of the airways to provocative stimuli through its primary function as a cellular barrier ...
M P, Sparrow, T I, Omari, H W, Mitchell
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2013
The intestinal epithelium is the body’s first line of defense against harmful contents of the gut, and defects in the epithelial barrier are thought to contribute to the initiation and perpetuation of inflammatory bowel diseases. Recent genome-wide association studies have identified a number of mutations in genes implicated in the regulation of the ...
Stefan Koch +2 more
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The intestinal epithelium is the body’s first line of defense against harmful contents of the gut, and defects in the epithelial barrier are thought to contribute to the initiation and perpetuation of inflammatory bowel diseases. Recent genome-wide association studies have identified a number of mutations in genes implicated in the regulation of the ...
Stefan Koch +2 more
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Innate immune sensing by epithelial barriers
Current Opinion in Immunology, 2021Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting, and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern recognition receptors in epithelial cells bind to diverse ligands, detecting pathogen components and behaviors and stimulating cell-autonomous immunity. In addition to
David A Constant +2 more
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Epithelial Barriers, Compartmentation, and Cancer
Science's STKE, 2004Epithelial cells, and the tight junctions between them, form a polarized barrier between luminal and serosal fluid compartments and segregate luminal growth factors from their basal-lateral receptors. Breakdown of this barrier should allow access of growth factors in the luminal fluid to their receptors on the basal-lateral cell membranes, as recently ...
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The epithelial barrier and immunoglobulin A system in allergy
Clinical & Experimental Allergy, 2016SummaryAirway and intestinal epithelial layers represent first‐line physical barriers, playing a key role in mucosal immunity. Barrier dysfunction, characterized by alterations such as disruption of cell–cell apical junctions and aberrant epithelial responses, probably constitutes early and key events for chronic immune responses to environmental ...
F M, Carlier, Y, Sibille, C, Pilette
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