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Innate immune sensing by epithelial barriers
Current Opinion in Immunology, 2021Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting, and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern recognition receptors in epithelial cells bind to diverse ligands, detecting pathogen components and behaviors and stimulating cell-autonomous immunity. In addition to
David A Constant +2 more
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Epithelial Barriers in Intestinal Inflammation
Antioxidants & Redox Signaling, 2011The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John +2 more
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Epithelial Barriers, Microbiota, and Colorectal Cancer
New England Journal of Medicine, 2013There is an established link between the inflammation process and the genesis of colorectal cancer. A recent study suggests that intestinal microbiota may have a mediatory role between the initial steps of tumorigenesis and the initiation of an immune response that influences clinical outcome.
Awen M, Gallimore, Andrew, Godkin
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The epithelial barrier and airway responsiveness
Canadian Journal of Physiology and Pharmacology, 1995Epithelial injury and bronchial hyperresponsiveness are commonly associated with airway disease, and are widely considered to occur as the result of inflammatory changes in the airway wall. Mechanistically, the airway epithelium may influence the sensitivity of the airways to provocative stimuli through its primary function as a cellular barrier ...
M P, Sparrow, T I, Omari, H W, Mitchell
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2013
The intestinal epithelium is the body’s first line of defense against harmful contents of the gut, and defects in the epithelial barrier are thought to contribute to the initiation and perpetuation of inflammatory bowel diseases. Recent genome-wide association studies have identified a number of mutations in genes implicated in the regulation of the ...
Stefan Koch +2 more
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The intestinal epithelium is the body’s first line of defense against harmful contents of the gut, and defects in the epithelial barrier are thought to contribute to the initiation and perpetuation of inflammatory bowel diseases. Recent genome-wide association studies have identified a number of mutations in genes implicated in the regulation of the ...
Stefan Koch +2 more
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Defective epithelial barrier function in asthma
Journal of Allergy and Clinical Immunology, 2011Asthma is a complex disease involving gene and environment interactions. Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities are required for disease expression. The bronchial epithelium forms the interface with the external environment and is pivotally involved in controlling tissue homeostasis through ...
Xiao C +17 more
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Glucocorticoids enhance airway epithelial barrier integrity
International Immunopharmacology, 2012Asthma is a chronic inflammatory disorder of the airways, but its pathogenesis is incompletely understood. While asthma is a complex disease caused by multiple factors, epithelial barrier damage is a cardinal feature. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs in the treatment of asthma.
Akiko, Sekiyama +7 more
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Epithelial Barriers, Compartmentation, and Cancer
Science's STKE, 2004Epithelial cells, and the tight junctions between them, form a polarized barrier between luminal and serosal fluid compartments and segregate luminal growth factors from their basal-lateral receptors. Breakdown of this barrier should allow access of growth factors in the luminal fluid to their receptors on the basal-lateral cell membranes, as recently ...
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Tryptase compromises corneal epithelial barrier function
Cell Biochemistry and Function, 2013Corneal epithelial barrier dysfunction is harmful to corneal health; the pathogenesis is unclear. This study aims to elucidate the mechanism by which tryptase compromises corneal epithelial barrier function. Human corneal epithelial cell line (HCE cells) was cultured into monolayers using as a study platform.
Qiyan, Li +5 more
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Journal of Agricultural and Food Chemistry, 2020
Destruction in intestinal barrier is concomitant with the intestinal diseases. There is growing evidence that tryptophan-derived intestinal bacterial metabolites play a critical role in maintaining the balance of intestinal mucosa.
Jiaojiao Li +5 more
semanticscholar +1 more source
Destruction in intestinal barrier is concomitant with the intestinal diseases. There is growing evidence that tryptophan-derived intestinal bacterial metabolites play a critical role in maintaining the balance of intestinal mucosa.
Jiaojiao Li +5 more
semanticscholar +1 more source