Results 221 to 230 of about 131,334 (259)

E-cadherin expression in the epithelial components of mammary phyllodes tumors

Human Pathology, 2012
Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interaction.
Richard Scolyer, Gary M Tse, Soon Lee
exaly   +4 more sources

Distribution and regulation of epithelial cadherin messenger ribonucleic acid and immunocytochemical localization of epithelial cadherin in the rat epididymis.

Endocrinology, 1992
The epithelium of the epididymis possesses an elaborate network of tight junctions between principal cells which is altered as a function of postnatal age. Cadherins are implicated in the formation of tight junctions. The objective of the present study was to determine whether RNA transcripts for cadherins were present in the epididymis, and if so, how
D G, Cyr, L, Hermo, O W, Blaschuk, B, Robaire   +3 more
openaire   +3 more sources

Epithelioid sarcoma: presence of vascular‐endothelial cadherin and lack of epithelial cadherin

Histopathology, 1998
AimsTo evaluate the pattern of cadherin expression in epithelioid sarcoma.Methods and resultsSeven epithelioid sarcomas were immunostained by a polyclonal antibody that detects all cadherin subtypes and by monoclonal antibodies that detect epithelial cadherin (E‐cadherin) and vascular‐endothelial cadherin (VE cadherin).
M E, Smith, J I, Brown, C, Fisher
openaire   +2 more sources

Thermodynamic Stability of Domain 2 of Epithelial Cadherin

Biochemistry, 2004
Cadherin is a cell adhesion molecule that participates in ordered calcium-dependent self-association interactions both between molecules on the same cell surface (cis-interactions) and on neighboring cell surfaces (trans-interactions). Cadherin is a transmembrane protein that has 3-7 independently folded beta-barrel extracellular domains. Both types of
Alka, Prasad, Nicole A, Housley, Susan, Pedigo   +2 more
openaire   +2 more sources

Cadherins and Epithelial-to-Mesenchymal Transition

2013
Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells are transcriptionally reprogrammed, resulting in decreased adhesion and enhanced migration or invasion. EMT occurs during different stages of embryonic development, including gastrulation and neural crest cell delamination, and is induced by a panel of specific transcription ...
Alexander, Gheldof, Geert, Berx
openaire   +2 more sources

Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia

American Journal of Physiology-Renal Physiology, 2000
Ischemic epithelial cells are characterized by disruption of intercellular junctions and loss of apical-basolateral protein polarity, which are normally dependent on the integrity of the adherens junction (AJ). Biochemical analysis of both whole ischemic kidneys and ATP-depleted Madin-Darby canine kidney (MDCK) cells demonstrated a striking loss of E ...
K T, Bush, T, Tsukamoto, S K, Nigam
openaire   +2 more sources

Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation

Journal of Cell Science, 2001
ABSTRACT MDCK cells were engineered to reversibly express mutant E-cadherin protein with a large extracellular deletion. Mutant cadherin overexpression reduced the expression of endogenous E-and K-cadherins in MDCK cells to negligible levels, resulting in decreased cell adhesion. Despite severe impairment of the cadherin adhesion system,
M L, Troxell, D J, Loftus, W J, Nelson, J A, Marrs   +3 more
openaire   +2 more sources

Epithelial Cell Shape: Cadherins and Small GTPases

Experimental Cell Research, 2000
Cadherins are cell-cell adhesion receptors that are essential for the establishment of the epithelial cell shape and maintenance of the differentiated epithelial phenotype. In order to show efficient adhesion, cadherin receptors require an association with actin filaments and the activity of RHO proteins.
openaire   +2 more sources

Differential expression of neural‐cadherin in pulmonary epithelial tumours

Histopathology, 2008
Aims:  Neural (N)‐cadherin belongs to a group of transmembrane molecules with a crucial role in tissue morphogenesis and maintenance of an epithelioid phenotype and increased N‐cadherin expression is implicated in tumour progression and dedifferentiation.
D L, Zynger, N D, Dimov, L C, Ho, W B, Laskin, A V, Yeldandi   +4 more
openaire   +2 more sources