Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection [PDF]
Pollens are well-known triggers of respiratory allergies and asthma. The pollen burden in today's ambient air is constantly increasing due to rising climate change and air pollution.
Gevaert, Kris+6 more
core +3 more sources
Mechanical Stress Inference for Two Dimensional Cell Arrays [PDF]
Many morphogenetic processes involve mechanical rearrangement of epithelial tissues that is driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular adhesion are not only the targets of regulation, but are themselves likely signals that coordinate developmental process.
arxiv +1 more source
Hyla versicolor-chrysoscelis Species Complex of Gray Treefrogs in Arkansas: Histological and Ultrastructural evidence [PDF]
We investigated the Hyla versicolor-chrysoscelis species complex (tetraploid and diploid species, respectively) of cryptic gray treefrogs from Arkansas using light and scanning electron microscopy.
Chaffin, Phyllis, Trauth, Stanley E.
core +2 more sources
Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis [PDF]
Tumorigenic transformation of human epithelial cells in vitro has been described experimentally as the potential result of a process known as spontaneous immortalization. In this process a generic series of cell state transitions occur in which normal epithelial cells acquire a senescent state, later surpassed to attain first a mesenchymal state and ...
arxiv
Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis [PDF]
In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy.
Boyle, Ross W.+7 more
core +1 more source
Loss of survivin in intestinal epithelial progenitor cells leads to mitotic catastrophe and breakdown of gut immune homeostasis [PDF]
A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. Survivin is highly expressed during embryogenesis and in several cancer types, but little is known about ...
Altieri+37 more
core +2 more sources
The overall goal was to generate an epithelial-mesenchymal transition (EMT) model using lens epithelial cells-induced pluripotent stem cells to elucidate EMT-regulatory factors during posterior capsular opacification (PCO).
Roy Joseph+3 more
doaj
Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface [PDF]
Respiratory tract infections are of significant concern in the agriculture industry. There is a requirement for the development of well-characterised in vitro epithelial cell culture models in order to dissect the diverse molecular interactions occurring
Berry, Catherine C.+3 more
core +2 more sources
Background TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essential for the ARF6-driven cell ...
Haruka Handa+5 more
doaj +1 more source
Active Vertex Model for Cell-Resolution Description of Epithelial Tissue Mechanics [PDF]
We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible to similar methods. The AVM combines the Vertex Model for confluent epithelial tissues with active matter dynamics.
arxiv