Results 11 to 20 of about 58,378 (265)

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Expression of Ki-67, p53, α-SMA and COX-2 in lichen planus and related lesions: A pilot study

Journal of Oral Biology and Craniofacial Research, 2019
Background: Researchers have struggled to understand the natural history of lesions presenting with both lichenoid features and epithelial dysplasia.
D.S. Sanketh, Karuna Kumari, Roopa S. Rao, Vanishree C. Haragannavar, Sachin C. Sarode, Gargi S. Sarode, A. Thirumal Raj, Shankargouda Patil   +7 more
doaj   +1 more source

Comparison of expression of myofibroblasts in normal oral mucosa, oral epithelial dysplasia, and oral squamous cell carcinoma using α-SMA and vimentin: An immunohistochemical study

Journal of Family Medicine and Primary Care, 2020
Background: Myofibroblasts are thought to play critical roles in inflammation, growth, repair, premalignancy, and malignancy. This study was done to evaluate, compare and co- relate the progressive increase in the immunohistochemical expression of ...
Amani Mahajan, Andleeb Manhas, Tania Aneja, Swati Parhar, Priyanka Kumari, Anubhuti, Harkanwal P Singh   +6 more
doaj   +1 more source

Morphometric analysis of suprabasal cell layer in oral epithelial dysplasia: A computer-assisted microscopic study

Journal of Pharmacy and Bioallied Sciences, 2020
Background: Oral leukoplakia is the most common precancerous lesion. Various grading systems based on histological findings have been proposed for dysplasia.
Viswanathan Prema, Thomson Thomas, Prasad Harikrishnan, Mani Viswanathan, Kenniyan Kumar Srichinthu, Krishnan Rajkumar   +5 more
doaj   +1 more source

Suprabasal expression of Ki-67 as a marker for the severity of oral epithelial dysplasia and oral squamous cell carcinoma

Contemporary Clinical Dentistry, 2013
Background: Transition of the normal oral epithelium to dysplasia and to malignancy is featured by increased cell proliferation. To evaluate the hypothesis of distributional disturbances in proliferating and stem cells in oral epithelial dysplasia and ...
Nidhi Dwivedi, Shaleen Chandra, Bina Kashyap, Vineet Raj, Akhil Agarwal   +4 more
doaj   +1 more source

Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia. [PDF]

PLoS ONE, 2016
Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA2 attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA2 ...
Michihiro Yoshida, Peijian He, C Chris Yun   +2 more
doaj   +1 more source

Oral Epithelial Dysplasia and Premalignancy [PDF]

Head and Neck Pathology, 2019
Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years.
openaire   +2 more sources

Psychosocial impacts of oral epithelial dysplasia

Journal of Oral Pathology & Medicine, 2021
Abstract Background The psychosocial impact of receiving the diagnosis of oral epithelial dysplasia, which presents up to 3.5% increased annual risk of mouth cancer, remains unknown. Using validated instruments, the present study aimed to investigate the prevalence and existing correlations ...
Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter   +3 more
openaire   +3 more sources

Effect of tobacco, alcohol, and smoking habits in oral precancer with histological proven epithelial dysplasia

Journal of Oral Biology and Craniofacial Research, 2012
Objectives: To assess the effect of risk factors tobacco, alcohol, and smoking habits in oral precancer patients with epithelial dysplasia status. Material and methods: The study sample included biopsy proven cases of 29 oral submucous fibrosis (OSMF ...
Seema Nayak, Saumya Chandra, Divya Mehrotra, Sumit Kumar, S.P. Agrawal, Sandeep Kumar, Madhu Mati Goel   +6 more
doaj   +1 more source