Results 21 to 30 of about 495,108 (198)

Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia. [PDF]

PLoS ONE, 2016
Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA2 attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA2 ...
Michihiro Yoshida, Peijian He, C Chris Yun   +2 more
doaj   +1 more source

Feasibility of recruitment to an oral dysplasia trial in the United Kingdom [PDF]

, 2012
Background: Oral epithelial dysplasia (OED) has a malignant potential. Therapeutic options for OED remain both limited and without good evidence. Despite surgery being the most common method of treating OED, recurrence and potentially significant ...
Nankivell, Paul, Mehanna, Hisham M., Michael Langman, Dunn, Janet A., Hisham Mehanna, Dunn, Janet, Nankivell, Paul; id_orcid, Langman, Michael J., Paul Nankivell, Janet Dunn, Mehanna, Hisham; id_orcid, Langman, Michael   +11 more
core   +1 more source

Oral Epithelial Dysplasia and Premalignancy [PDF]

Head and Neck Pathology, 2019
Leukoplakia and erythroplakia are two entities under the moniker of "oral potentially malignant disorders" that are highly associated with the presence of oral epithelial dysplasia (OED) at first biopsy, while lesions of submucous fibrosis develop OED after being present for years.
openaire   +2 more sources

Effect of tobacco, alcohol, and smoking habits in oral precancer with histological proven epithelial dysplasia

Journal of Oral Biology and Craniofacial Research, 2012
Objectives: To assess the effect of risk factors tobacco, alcohol, and smoking habits in oral precancer patients with epithelial dysplasia status. Material and methods: The study sample included biopsy proven cases of 29 oral submucous fibrosis (OSMF ...
Seema Nayak, Saumya Chandra, Divya Mehrotra, Sumit Kumar, S.P. Agrawal, Sandeep Kumar, Madhu Mati Goel   +6 more
doaj   +1 more source

Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa [PDF]

, 2002
Background: Minichromosome maintenance (Mcm) proteins are essential for eukaryotic DNA replication, and their expression implies potential for cell proliferation.
Going, J.J., Keith, W.N., Stuart, RC, Stuart, R.C., Stoeber, K, Neilson, L, Stoeber, K., Williams, G.H., Williams, GH, Going, JJ, Keith, WN, Neilson, L.   +11 more
core   +1 more source

Assessment and comparison of p53 and p63 expression in oral epithelial dysplasia and squamous cell carcinoma

SRM Journal of Research in Dental Sciences, 2014
Aim: p53 and p63 are the important genes associated with oral cancer. The aim of this study was to evaluate and compare the immunohistochemical expression of p53 and p63 in oral epithelial dysplasia and squamous cell carcinoma (SCC).
Smitha Sammith Shetty, Rekha Krishnapillai, Sudeendra Prabhu   +2 more
doaj   +1 more source

Psychosocial impacts of oral epithelial dysplasia

Journal of Oral Pathology & Medicine, 2021
Abstract Background The psychosocial impact of receiving the diagnosis of oral epithelial dysplasia, which presents up to 3.5% increased annual risk of mouth cancer, remains unknown. Using validated instruments, the present study aimed to investigate the prevalence and existing correlations ...
Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter   +3 more
openaire   +3 more sources

Intestinal epithelial dysplasia

Pacific Medical Journal, 2020
The article presents a clinical case of intestinal epithelial dysplasia (tufting enteropathy), a rare disease which relates to congenital diarrheas, has a particular clinical presentation and is life-threating. The diagnosis was confirmed by histological examination and electronic microscopy of mucous membrane of small intestine. Additional evidence is
T. E. Taranushenko, E. M. Vasilyeva, E. V. Antsiferova, L. N. Karpova, Y. S. Shamova   +4 more
openaire   +2 more sources

LIHNCS - Lugol's iodine in head and neck cancer surgery : a multicentre, randomised controlled trial assessing the effectiveness of Lugol’s iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma : study protocol for a randomised controlled trial [PDF]

, 2013
Background: Oral cavity and oropharynx cancer are increasing in incidence worldwide but survival outcomes have not significantly improved over the last three decades. The presence of dysplasia or carcinoma in situ at surgical margins following resection
McMahon, Jeremy, Mehanna, Hisham M., McConkey, Christopher C., Hisham Mehanna, Sutton, David N., Dunn, Janet, Cymerman, James A, McCaul, James A, Sutton, David N, Shaw, Richard, James A McCaul, Dunn, Janet A., McCaul, James A., Jeremy McMahon, David N Sutton, Cymerman, James A., Hislop, Stuart, McConkey, Chris, James A Cymerman, Stuart Hislop, Richard Shaw, Mehanna, Hisham; id_orcid, Chris McConkey, Janet Dunn   +23 more
core   +1 more source

Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia [PDF]

, 2009
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD.
Hogmalm, Anna
core   +1 more source