Results 51 to 60 of about 182,825 (308)

Incomplete pregnancy and risk of ovarian cancer: Results from two Australian case–control studies and systematic review

, 2009
Although full-term pregnancies reduce the risk of ovarian cancer, it has not been conclusively established whether incomplete pregnancies also influence risk.
Dick, Marie-Louise B., Purdie, David M., Dick, Marie Louise B, Green, Adele C., The Australian Ovarian Cancer Study Group, Siskind, Vic, Siskind, Victor, Australian Cancer Study Group (Ovarian Group)   +7 more
core   +1 more source

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]

, 2003
BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
Pauline A Whitehouse, Federica Di Nicolantonio, Whitehouse, PA, Cree, IA, Bernard R Higgins, Di Nicolantonio Federica, Mercer Stuart J, Cree Ian A, Knight, LA, Higgins, BR, Osborne Richard, Kurbacher, CM, Kurbacher Christian M, Di Nicolantonio, Federica, Stuart J Mercer, Osborne, R, Richard Osborne, Alan Lamont, Whitehouse Pauline A, Louise A Knight, Sanjay Sharma, Di Nicolantonio, F, Neale Michael H, Andrew C Hindley, Hindley Andrew C, Sharma Sanjay, Knight Louise A, Lamont, A, Higgins Bernard R, Neale, MH, Ian A Cree, Hindley, AC, Mercer, SJ, Lamont Alan, Michael H Neale, Christian M Kurbacher, Sharma, S   +36 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study

Frontiers in Oncology, 2019
Serpin family D member 1 (SERPIND1) belongs to the serine protease inhibitor family. Its role in cancers has gradually attracted interest from researchers in recent years.
Qian Guo, Qian Guo, Qian Guo, Liancheng Zhu, Caixia Wang, Shuang Wang, Xin Nie, Juanjuan Liu, Qing Liu, Yingying Hao, Xiao Li, Bei Lin, Bei Lin, Bei Lin   +13 more
doaj   +1 more source

p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker [PDF]

, 2010
The oncolytic adenovirus dl922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers.
Balkwill, F.R., Magdalena B Flak, Balkwill, FR, Chelala, C, McNeish, IA, Archibald, Kyra, Pirlo, K.J., Chelala, C., Iain A McNeish, Flak, M.B., Salako, MA, Pirlo, KJ, Katrina J Pirlo, Salako, M.A., Lockley, M, Connell, C.M., Mcneish, I.A., Lockley, M., Wheatley, S.P., Wheatley, SP, Flak, Magdalena B; id_orcid, Archibald, K, Archibald, K., Flak, MB, Michael A Salako, Michelle Lockley, Claude Chelala, McNeish, Iain A, Kyra Archibald, Frances R Balkwill, Pirlo, Katrina J, Lockley, Michelle, Connell, CM, Sally P Wheatley, Chelala, Claude, Balkwill, Frances R, Connell, Claire M, Claire M Connell, Salako, Michael A, Wheatley, Sally P   +39 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses [PDF]

, 2011
Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy.
Fuerst, Sophie, Lenhard, Miriam, Katja Krocker, Karin Hofmann, Linda Hertlein, Sophie Fürst, Dorothea Nagel, Mayr, Doris, Hofmann, Karin, Alexander Burges, Stieber, Petra, Kirschenhofer, Angela, Miriam Lenhard, Angela Kirschenhofer, Krocker, Katja, Burges, Alexander, Doris Mayr, Hertlein, Linda, Nagel, Dorothea, Petra Stieber   +19 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Predictive value of CA 125 and CA 72-4 in ovarian borderline tumors [PDF]

, 2009
Background: The aim of this study was to assess the prognostic value of cancer antigen (CA) 125 and CA 72-4 in patients with ovarian borderline tumor (BOT).
Linda Hertlein, Klaus Friese, Dorothea Nagel, Mayr, Doris, Alexander Burges, Stieber, Petra, Nehring, Stefanie, Kirschenhofer, Angela, Miriam S. Lenhard, Angela Kirschenhofer, Friese, Klaus, Burges, Alexander, Doris Mayr, Lenhard, Miriam S., Hertlein, Linda, Nagel, Dorothea, Stefanie Nehring, Petra Stieber   +17 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source