Results 71 to 80 of about 182,825 (308)

Ovarian cancer serum biomarker discovery using proteomics [PDF]

, 2008
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection.
Kabir, M.
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Effect of different treatment modalities on the prognosis of stage IV epithelial ovarian cancer: analysis of the SEER database

BMC Women's Health
Background The prognosis of advanced ovarian cancer is often poor. Although there are several treatment options for stage IV epithelial ovarian cancer, it is not clear which treatment will benefit the patient’s prognosis.We conducted an analysis using ...
Shuyuan Zhang, Hongyong Zhang, Naer Jia, Suo Suo, Jianfeng Guo   +4 more
doaj   +1 more source

Relationship Between Age And Menopausal Status With The Incident Of Epithelial Ovarian Carcinoma At RSUP Dr. M. Djamil Padang

Andalas Obstetrics and Gynecology Journal
Introduction : High Grade Serous Ovarian Carcinoma (HGSOC) been the dominant subtype and accounted for the highest mortality rate of epithelial ovarian cancer.
Carmiyana Puja Harsby, Syamel Muhammad, Yenita Yenita   +2 more
doaj   +1 more source

Advances in treatment of epithelial ovarian cancer [PDF]

, 2006
2006-01Since most cases of epithelial ovarian cancer are advanced at diagnosis, this disease is one of the most lethal malignancies of the female genital tract.
柴田, 清住, Kajiyama, Hiroaki, Sibata, Kiyosumi, Kikkawa, Fumitaka, Nawa, Akihiro, Nomura, Seiji, 梶山, 広明, Ino, Kazuhiko, 野村, 誠二, 吉川, 史隆, 那波, 明宏   +10 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma

Clinical and Translational Medicine, 2021
Background High‐grade serous ovarian carcinoma (HGSOC) is the most common and aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of this disease remain incompletely understood.
Qian Hao, Jiajia Li, Qinghua Zhang, Fei Xu, Bangxiang Xie, Hua Lu, Xiaohua Wu, Xiang Zhou   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Epigenetic therapy for the treatment of epithelial ovarian cancer: A clinical review

Gynecologic Oncology Reports, 2017
Despite a good initial response to chemotherapy, the majority of patients with epithelial ovarian cancer will eventually recur and die of their disease.
Haller J. Smith, J. Michael Straughn, Donald J. Buchsbaum, Rebecca C. Arend   +3 more
doaj   +1 more source

Modelling neoplastic progression in epithelial ovarian cancer

, 2010
A national screening programme could significantly reduce mortality from epithelial ovarian cancer (EOC). The biological events that occur in the early stages of development of EOCs remain poorly understood, thus hindering the discovery of biomarkers ...
Lawrenson, K.
core