Results 91 to 100 of about 182,825 (308)

Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis [PDF]

, 2015
WV is a SULSA Systems Biology Prize PhD Student; VAS is supported by the BBSRC Research Council [grant number BB/F001398/1] and Medical Research Scotland [grant number FRG353].
Smith, V. Anne, Verleyen, Wim, Smith, V Anne, Harrison, David James, Langdon, Simon P, Langdon, Simon P., Faratian, Dana, Harrison, David J.   +7 more
core   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

BRCA1 Gene Q356R (1186A=G) Polymorphism and Epithelial Ovarian Cancer Incidence

Indonesian Journal of Obstetrics and Gynecology, 2015
Objective: To determine the association between BRCA1 gene Q356R (1186A=G) polymorphism and epithelial ovarian cancer incidence. Methods: This study is an observational analytic study with casecontrol study design.
Benyamin Rakhmatsyah, Agustria Z Saleh, Rizal Sanif, Yuwono Yuwono   +3 more
doaj   +1 more source

Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection

, 2010
In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Brigitte E. Miller, James W. Orr, Robert W. Holloway, Jinghua Zhao, Ronald D. Alvarez, Greg P. Bertenshaw, James P. Mapes, Michael E. McCollum, James F. Barter, Glenn E. Bigsby, Brian C. Mansfield, Partha Seshaiah, Tzong-Hao Chen, Paul A. DiSilvestro, Lynda D. Roman, Beth Y. Karlan, Laurie L. Stephen, Ping F. Yip, Suraj Amonkar, Katharine J. Bergstrom, Eva Chalas   +20 more
core  

Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment [PDF]

, 2015
Ovarian cancers are still the most lethal gynecologic malignancy. As a novel strategy against this poor outcome cytotoxic alterations induced by a pro-oxidant treatment on human ovarian endometrioid carcinoma (MDAH 2774) cells are revisited by using ...
Gilloteaux, Jacques, Jacques Gilloteaux, Deborah Neal, James M. Jamison, Summers, J.L., Lau, H. Lee, Gourari, Ioulia, H. Lee Lau, J.L. Summers, Summers, J. L., Neal, Deborah, Jamison, James M., Ioulia Gourari   +12 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Multiple metastases from ovarian cancer

South African Journal of Obstetrics and Gynaecology, 2014
Epithelial ovarian cancer is one of the most common ovarian tumours. Ovarian cancer affects women in the age group >60 years much more frequently than younger women.
Daleep Singh, Shankar Jakhar, Puneet Bagri, Akhil Kapoor, H Kumar   +4 more
doaj   +1 more source

Proteomic analysis of cell models of ovarian cancer tumour suppression

, 2010
Epithelial ovarian cancer (EOC) is the most common form of gynaecological malignancy in the developed world. Identifying molecular markers of disease may provide novel approaches to screening and could enable targeted treatment and the design of novel
Sinclair, J.R.
core  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

HER2/Neu Expression was Different between Benign, Borderline and Malignant Epithelial Ovarian Tumors

Indonesian Journal of Obstetrics and Gynecology, 2014
Objective: To determine the difference of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumor. Method: An analytic cross-sectional study was performed on 49 samples of epithelial ovarian cases which were divided into three
Yona S. Hadisubroto, Ketut Suwiyoga
doaj   +1 more source