Results 81 to 90 of about 3,788,205 (194)

Engrailed-2 (EN2) – a novel biomarker in epithelial ovarian cancer

BMC Cancer, 2018
Background Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in
Sophie Elena McGrath, Nicola Annels, Thumuluru K. Madhuri, Anil Tailor, Simon A. Butler-Manuel, Richard Morgan, Hardev Pandha, Agnieszka Michael   +7 more
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Clinical resistance to platinum chemotherapy in ovarian cancer [PDF]

, 2009
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established.
Newton, C., Newton, C
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The tumor suppressor protein OPCML potentiates anti-EGFR and anti-HER2 targeted therapy in HER2-positive ovarian and breast cancer. [PDF]

, 2017
OPCML is a tumor suppressor gene that is frequently inactivated in ovarian cancer and many other cancers by somatic methylation. We have previously shown that OPCML exerts its suppressor function by negatively regulating a spectrum of receptor tyrosine ...
Vaughan, S, Jane Antony, Karali, E, Imoh S. Okon, Justin Stebbing, Gabra, H, Arthur B. McKie, Antony, J, McKie, AB, Sebastian Vaughan, Zanini, E, Louay S. Louis, Evdoxia Karali, Mona El-Bahrawy, Louis, LS, Stebbing, J, El-Bahrawy, M, Okon, IS, Chiara Recchi, Hani Gabra, Recchi, C, Elisa Zanini   +21 more
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Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis [PDF]

, 1999
We have performed representational difference analysis (RDA) on DNA from tumor cells and normal fibroblasts isolated from the ascites of a patient with ovarian cancer. Five of six products of the RDA were homozygously deleted from the tumor DNA.
Perry, P, Morrison, H, Gabra, H, Taylor, K J, Watson, J E, Porteous, D J, Rabiasz, G J, Smyth, J F   +7 more
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LAMP3 expression correlated with poor clinical outcome in human ovarian cancer

Tumor Biology, 2017
Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy.
Di Wang, Xuemin Cao, Yuquan Zhang, Yuanlin Liu, Chan Yao, Wenliang Ge, Yunzhao Xu   +6 more
doaj   +1 more source

Ocena stężeń naskórkowego czynnika wzrostu w surowicy kobiet leczonych z powodu nabłonkowych guzów jajnika

Menopause Review, 2011
Background: Epithelial ovarian cancer is the leading cause of cancer deaths resulting from gynaecological malignancies. Like most other epithelial tumours, epithelial ovarian cancer spreads initially by direct extension into adjacent organs.
Marek Grabiec, Małgorzata Walentowicz-Sadłecka, Paweł Sadłecki   +2 more
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Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas : an exception to the norm

, 2007
Cancer that arises from the ovarian surface epithelium (OSE) accounts for approximately 90% of human ovarian cancer, and is the fourth leading cause of cancer-related deaths among women in developed countries.
Thompson, Erik W., Ahmed, Nuzhat, Quinn , Michael A.   +2 more
core   +1 more source

The Characteristics of Sociodemography, Histopathologic Features, Stage, and Management of Ovarian Cancer in Dr. Ramelan Navy Hospital Surabaya

Indonesian Journal of Cancer
Background: Ovarian cancer is considered a silent killer disease, mainly due to the late diagnosis. It is often diagnosed at an advanced stage, thus increasing the mortality rate.
Karina Rahmalia, Ketut Edy Sudiarta, Herin Setianingsih, Wienta Diarsvitri   +3 more
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Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Vinay Varadan, Hoon Kim, John Watkinson, Dimitris Anastassiou   +3 more
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Attenuated Salmonella typhimurium L forms suppress tumor growth and promote apoptosis in murine ovarian tumors

Scientific Reports
To study the effects of attenuated Salmonella typhimurium L forms on the in vivo tumorigenicity and apoptosis of murine epithelial ovarian cancer cells, as well as the related mechanisms.
Yunjie Zhang, Ziqing Tang, Yidan Shao, Xiaoli Yue, Yifan Chu, Dengyu Chen   +5 more
doaj   +1 more source