Results 41 to 50 of about 182,825 (308)

Epithelial ovarian cancer: An overview

World Journal of Translational Medicine, 2014
Ovarian cancer is the second most common gynecological cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies.
Arpita, Desai, Jingyao, Xu, Kartik, Aysola, Yunlong, Qin, Chika, Okoli, Ravipati, Hariprasad, Ugorji, Chinemerem, Candace, Gates, Avinash, Reddy, Omar, Danner, Geary, Franklin, Anachebe, Ngozi, Guilherme, Cantuaria, Karan, Singh, William, Grizzle, Charles, Landen, Edward E, Partridge, Valerie Montgomery, Rice, E Shyam P, Reddy, Veena N, Rao   +19 more
openaire   +2 more sources

The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer

, 2002
Background: In sporadic ovarian cancer, we have previously reported allele loss at D6S193 (62%) on chromosome 6q27, which suggested the presence of a putative tumour suppressor gene.
Liu, Y, Phillippa Dodds, Charnock, FML, Dodds, P, Dunham Ian, Liu Ying, Wells R Spencer, Gracy Emilion, Ganesan Trivadi S, Beck, Stephan, Charnock, F Mark L, Emilion, G, Stephan Beck, Mungall, Andrew J, Ian Dunham, F Mark L Charnock, Wells, RS, Ganesan, TS, Emilion, Gracy, Dunham, I, Dodds Phillippa, Beck Stephan, Emilion Gracy, Wells, R Spencer, Dunham, Ian, Mungall Andrew J, Andrew J Mungall, Ying Liu, R Spencer Wells, Beck, S, Liu, Ying, Mungall, AJ, Trivadi S Ganesan, Charnock F Mark L, Dodds, Phillippa, Ganesan, Trivadi S   +35 more
core   +1 more source

Paraneoplastic thrombocytosis in ovarian cancer [PDF]

, 2012
<p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Han, H.D., Wang, R., Collins, K., Drew, A.F., Vasquez, H.G., Coward, J., Deavers, M.T., Urbauer, D., Lamkin, D., Matsuo, K., Sood, A.K., Stone, R.L., Lopez-Berestein, G., Bottsford-Miller, J., Shahzad, M.M.K., King, E.R., Mcneish, I.A., Afshar-Kharghan, V., Gershenson, H., Rupairmoole, R., Ahn, E.H., DeGeest, K., Gushiken, F., Tekedereli, I., Ozpolat, B., Nick, A.M., Chiu, W., Armaiz-Pena, G.N., Lutgendorf, S.K., Landen, C.N., Bond, V.K., Balkwill, F., Hu, W., Pecot, C.V.   +33 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The peritoneal tumour microenvironment of high-grade serous ovarian cancer [PDF]

, 2012
High-grade serous ovarian cancer (HGSC) disseminates early and extensively throughout the peritoneal space, causing multiple lesions that are a major clinical problem. The aim of this study was to investigate the cellular composition of peritoneal tumour
Balkwill, F.R., Felicity N. E Gavins, Gould, D, Balkwill, FR, McNeish, IA, Gavins, F.N.E., Kulbe, H., Nourshargh, S., Perretti, M, Iain A McNeish, Perretti, M., Cooper, D., Thompson, R., Leinster, DA, D Andrew Leinster, Darren P Ennis, Richard Thompson, Gavins, FNE, Ennis, DP, Gemma Everitt, Dianne Cooper, Kulbe, H, Lockley, M, Nourshargh, S, Mauro Perretti, Mcneish, I.A., Lockley, M., Michelle Lockley, Everitt, G, Ennis, D.P., Frances R Balkwill, Gould, D., Leinster, D.A., Cooper, D, Sussan Nourshargh, Thompson, R, Hagen Kulbe, David Gould, Everitt, G.   +38 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.

Folia Histochemica et Cytobiologica, 2010
The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients.
Jacek Nikliński, Piotr S Bernaczyk, Wieslawa Niklińska, Magdalena Garbowicz, Slawomir J Terlikowski, Bozena Dobrzycka, Maciej Kinalski, Lech Chyczewski   +7 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Prostate cancer gene expression marker 1 (PCGEM1) is a long noncoding RNA (lncRNA) and is well known as a promoter in prostate cancer and osteoarthritis synoviocytes. However, the role PCGEM1 plays in epithelial ovarian cancer is unknown.
Shuo Chen, Li-li Wang, Kai-xuan Sun, Yao Liu, Xue Guan, Zhi-hong Zong, Yang Zhao   +6 more
doaj   +1 more source