Results 81 to 90 of about 276,970 (298)
Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma
Clinical and Translational Medicine, 2021 Background High‐grade serous ovarian carcinoma (HGSOC) is the most common and aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of this disease remain incompletely understood.
Qian Hao +7 more
doaj +1 more source
A Robust Gene Expression Prognostic Signature for Overall Survival in High-Grade Serous Ovarian Cancer. [PDF]
, 2019 The objective of this research was to develop a robust gene expression-based prognostic signature and scoring system for predicting overall survival (OS) of patients with high-grade serous ovarian cancer (HGSOC).
Hang, Bo +8 more
core
Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors [PDF]
, 2018 Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant.
Codacci-Pisanelli, G +4 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Epigenetic therapy for the treatment of epithelial ovarian cancer: A clinical review
Gynecologic Oncology Reports, 2017 Despite a good initial response to chemotherapy, the majority of patients with epithelial ovarian cancer will eventually recur and die of their disease.
Haller J. Smith +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Development of A Mouse Model of Menopausal Ovarian Cancer
Frontiers in Oncology, 2014 Despite significant understanding of the genetic mutations involved in ovarian epithelial cancer and advances in genomic approaches for expression and mutation profiling of tumor tissues, several key questions in ovarian cancer biology remain enigmatic:
Elizabeth R. Smith +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Treatment of recurrent epithelial ovarian cancer
Therapeutics and Clinical Risk Management, 2009 Carmela Pisano, Giovanni S Bruni, Gaetano Facchini, Claudia Marchetti, Sandro PignataOncologia Medica, Dipartimento Uro-Ginecologico, Istituto Nazionale Tumori, Napoli, ItalyAbstract: Epidemiologic analysis reveals that the mortality rate from ovarian ...
Carmela Pisano +4 more
doaj
Tumor Biology, 2017 As a crucial member of the small ubiquitin-like modifier system, SUMO-specific protease 3, was identified to be essential for cell proliferation and ribosomal RNA processing.
Jialin Cheng +10 more
doaj +1 more source