Results 221 to 230 of about 212,176 (344)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.

J Am Soc Nephrol, 2023
Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DCA, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D.   +11 more
europepmc   +1 more source

Two Functional Epithelial Sodium Channel Isoforms Are Present in Rodents despite Pronounced Evolutionary Pseudogenization and Exon Fusion. [PDF]

Mol Biol Evol, 2021
Gettings SM, Maxeiner S, Tzika M, Cobain MRD, Ruf I, Benseler F, Brose N, Krasteva-Christ G, Vande Velde G, Schönberger M, Althaus M.   +10 more
europepmc   +1 more source

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.

Gene, 2016
Israel Hanukoglu, A. Hanukoglu
semanticscholar   +1 more source

Epithelium‐Inspired, Ultrahigh‐Toughness, Ultralow‐Hysteresis, and Highly Compressible Polymer Hydrogels as Self‐Powered, Visual, and Underwater Strain Sensors

Advanced Science, EarlyView.
Inspired by epithelial tissue, epithelium‐like structure hydrogels are synthesized. The as‐prepared hydrogels exhibit ultrahigh toughness, ultralow hysteresis, and ultrahigh compressibility, which can be utilized as self‐powered and visual strain sensors.
Yutang Zhou, Honghao Shu, Yuhuan Yao, Bolin Lu, Wenbin Zhong   +4 more
wiley   +1 more source

Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins. [PDF]

Biophys J, 2021
Grant SN, Lester HA.
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithelial Sodium Channel Activity. [PDF]

Biology (Basel)
Ramsay H, Yu L, Alousi FF, Alli AA.
europepmc   +1 more source

Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways.

American Journal of Respiratory and Critical Care Medicine, 2016
J. Reihill, B. Walker, R. Hamilton, T. Ferguson, J. Elborn, M. Stutts, B. Harvey, V. Saint-Criq, S. Hendrick, S. Martin   +9 more
semanticscholar   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source