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Single-channel recordings from amiloride-sensitive epithelial sodium channel
American Journal of Physiology-Cell Physiology, 1985We report here the first evidence in intact epithelial cells of unit conductance events from an amiloride-sensitive Na+ channel. The events were observed when patch-clamp recordings were made from the apical surface of cultured epithelial kidney cells (A6). The channel characteristics are as follows.
K L, Hamilton, D C, Eaton
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Epithelial Sodium Channel in Planar Lipid Bilayers
2006Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in sodium handling, they serve diverse functions in many tissues. Improper functioning of ENaC has been implicated in several diseases, including salt-sensitive hypertension (Liddle's syndrome), salt-wasting ...
Bakhrom K, Berdiev, Dale J, Benos
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The epithelial sodium channel has a role in breast cancer cell proliferation
Breast Cancer Research and Treatment, 2021A. Ware +4 more
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1986
Epithelial Na+ channels form an essential component of the Na+ reabsorptive system in a variety of tissues. They permit entry of Na+ into the epithelial cell from the outer fluid compartment, e.g., urine, feces, sweat. Furthermore, they regulate the reabsorptive flow of Na+ across many epithelia and thus are critical to the maintenance of constant salt
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Epithelial Na+ channels form an essential component of the Na+ reabsorptive system in a variety of tissues. They permit entry of Na+ into the epithelial cell from the outer fluid compartment, e.g., urine, feces, sweat. Furthermore, they regulate the reabsorptive flow of Na+ across many epithelia and thus are critical to the maintenance of constant salt
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Epithelial sodium channel, salt intake, and hypertension
Current Hypertension Reports, 2003The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron. This channel is responsible for salt reabsorption in the kidney and can cause human diseases by increasing channel function in Liddle's syndrome,
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Amiloride-Sensitive Epithelial Sodium Channels
1986Electrically high-resistance epithelia actively transport sodium from the luminal side to the blood (Macknight et al., 1980). The first step in this transepithelial movement of Na+ is the facilitated diffusion of this ion across the luminal or apical membrane down its electrochemical potential energy gradient.
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Sodium channel Nax is a regulator in epithelial sodium homeostasis
Science Translational Medicine, 2015Wei Xu +13 more
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Epithelial sodium channels (ENaC)
British Journal of Pharmacology, 2006S P H Alexander, A Mathie, J A Peters
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Fundamentals, status and promise of sodium-based batteries
Nature Reviews Materials, 2021Robert E Usiskin +2 more
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Recycling of sodium-ion batteries
Nature Reviews Materials, 2023Yun Zhao, Naser Tavajohi Hassan Kiadeh
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