Results 181 to 190 of about 10,384 (209)

The epithelial sodium channel (ENaC): new insights into ENaC gating

Pflugers Archiv European Journal of Physiology, 2003
Bernard C Rossier, Rossier Bernard C
exaly   +5 more sources

Identification of Amino Acid Residues in the α, β, and γ Subunits of the Epithelial Sodium Channel (ENaC) Involved in Amiloride Block and Ion Permeation

Journal of General Physiology, 1997
The amiloride-sensitive epithelial Nachannel (ENaC) is a heteromultimeric channel made of three αβγ subunits. The structures involved in the ion permeation pathway have only been partially identified, and the respective contributions of each subunit in ...
Laurent Schild, Ivan Gautschi, Dmitri Firsov   +2 more
exaly   +2 more sources

Hyperuricemia induces hypertension through activation of renal epithelial sodium channel (ENaC)

Metabolism: Clinical and Experimental, 2016
Yujie Huang, Jing Xing, Dongming Su
exaly   +2 more sources

Incorporation of the δ-subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis

Journal of Biological Chemistry, 2018
The epithelial sodium channel (ENaC) is a critical regulator of vertebrate electrolyte homeostasis. ENaC is the only constitutively open ion channel in the degenerin/ENaC protein family, and its expression, membrane abundance, and open probability ...
Lukas Wichmann, Alexander Perniss, Ivan Manzini   +2 more
exaly   +2 more sources

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis lung disease

Expert opinion on therapeutic targets, 2018
Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR anion channel.
P. J. Moore, R. Tarran
semanticscholar   +1 more source

Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ

Bioscience, Biotechnology and Biochemistry, 2019
The epithelial sodium channel (ENaC) plays a pivotal role in sodium homeostasis, and the development of drugs that modulate ENaC activity is of great potential therapeutic relevance.
Yoichi Kasahara, Takanobu Sakurai, Masataka Narukawa   +2 more
exaly   +2 more sources

Epithelial Sodium Channels (ENaCs)

2015
Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
openaire   +1 more source

The epithelial sodium channel (ENaC) is intracellularly located as a tetramer

Pfl�gers Archiv European Journal of Physiology, 2002
The epithelial sodium channel (ENaC) plays an important role in Na(+) homeostasis by determining the Na(+) transport rate in so-called end-organs such as the renal collecting duct, distal colon, salivary and sweat gland ducts. ENaC is formed by heteromultimerization of three homologous subunits, termed alpha, beta, and gamma ENaC.
Dijkink, L., Hartog, A., Os, C.H. van, Bindels, R.J.M.   +3 more
openaire   +3 more sources

Regulation of the epithelial sodium channel (ENaC) by accessory proteins

Current Opinion in Nephrology and Hypertension, 2000
The epithelial sodium channel (ENaC) plays a key role in the regulation of fluid absorption in the kidney, lung, colon and exocrine glands, and in the regulation of blood pressure. Abnormal functioning of ENaC is associated with several human diseases, including pseudohypoaldosteronism type I, Liddle's syndrome, pulmonary edema, and cystic fibrosis ...
openaire   +2 more sources

ClC-5 Chloride Channel Alters Expression of the Epithelial Sodium Channel (ENaC)

Journal of Membrane Biology, 2004
ClC-5 chloride channels and epithelial sodium channels (ENaC) are present in many cell types including airway and retinal epithelia. Since ENaC activity is known to be affected by chloride transport, we co-injected Xenopus oocytes with cRNAs encoding ENaC and ClC-5 to investigate whether channel currents are impacted by heterologous co-expression of ...
L, Mo, N K, Wills
openaire   +2 more sources