Results 11 to 20 of about 244,147 (243)
The Epithelial-to-Mesenchymal Transition in Cancer [PDF]
Cancers, 2018 The epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...].
J. Roche
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TGF-β-induced epithelial to mesenchymal transition [PDF]
Cell Research, 2009 During development and in the context of different morphogenetic events, epithelial cells undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT). In this process, the cells lose their epithelial characteristics, including their polarity and specialized cell-cell contacts, and acquire a migratory behavior, allowing ...
Jian Xu, Samy Lamouille, R. Derynck
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Epithelial‐to‐mesenchymal transitions in the liver† [PDF]
Hepatology, 2009 The outcome of liver injury is dictated by the effectiveness of repair. Successful repair (i.e., regeneration) results in replacement of dead epithelial cells with healthy epithelial cells, and reconstructs normal hepatic structure and function. Liver regeneration is known to involve replication of surviving mature hepatocytes and bile duct cells. This
Steve S, Choi, Anna Mae, Diehl
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Epithelial to Mesenchymal Transition in Gingival Overgrowth [PDF]
The American Journal of Pathology, 2010 Epithelial to mesenchymal transition (EMT) occurs normally in development. In pathology, EMT drives cancer and fibrosis. Medication with phenytoin, nifedipine, and cyclosporine-A often causes gingival overgrowth. Based partly on the histopathology of gingival overgrowth, the present study investigates the hypothesis that EMT could contribute to its ...
Siddika Selva, Sume +4 more
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Epithelial‐to‐mesenchymal‐like transition events in melanoma [PDF]
The FEBS Journal, 2021 Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that nonepithelial tumors, including melanoma, can also gain mesenchymal‐like properties that increase their ...
Pedri, Dennis +4 more
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MicroRNA Regulation of Epithelial to Mesenchymal Transition [PDF]
Journal of Clinical Medicine, 2016 Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo resistance, metastatic dissemination and fibrosis, amongst others.
Mohammed Abba +3 more
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Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon
World Journal of Gastroenterology, 2012 Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinogenesis and cancer invasion, chronic ...
Ferenc, Sipos, Orsolya, Galamb
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Epithelial to mesenchymal transition and breast cancer [PDF]
Breast Cancer Research, 2009 Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site.
Tomaskovic-Crook, Eva +2 more
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TGF-β and epithelial-to-mesenchymal transitions [PDF]
Oncogene, 2005 Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular mediators that control epithelial plasticity will be required in order to develop viable therapeutic approaches targeting epithelial-to-mesenchymal transition (EMT), an ...
Jiri, Zavadil, Erwin P, Böttinger
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TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Cellular and Molecular Life Sciences, 2019 Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune ...
W. Hua +4 more
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