Results 21 to 30 of about 207,813 (264)

Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis

Particle and Fibre Toxicology, 2023
Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung diseases worldwide, for which there is a lack of effective therapeutic drugs and tools.
Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang, Jie Chao   +10 more
doaj   +1 more source

Clinical significance of epithelial‐mesenchymal transition [PDF]

Clinical and Translational Medicine, 2014
AbstractThe concept of epithelial‐mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research community. Thousands of scientific reports investigated changes in gene, mRNA and protein expression compatible with EMT and their possible ...
Konrad Steinestel, Stefan Eder, Andres Jan Schrader, Julie Steinestel   +3 more
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Protons sensitize epithelial cells to mesenchymal transition. [PDF]

PLoS ONE, 2012
Proton radiotherapy has gained more favor among oncologists as a treatment option for localized and deep-seated tumors. In addition, protons are a major constituent of the space radiation astronauts receive during space flights.
Minli Wang, Megumi Hada, Janapriya Saha, Deepa M Sridharan, Janice M Pluth, Francis A Cucinotta   +5 more
doaj   +1 more source

Understanding the relationship between circulating platelets and epithelial to mesenchymal transition – a step towards in discovering new epithelial ovarian cancer targeted therapies [PDF]

Romanian Medical Journal, 2022
In the last decades understanding the relationship between the circulating platelets and the biological aggressivity of ovarian cancer gave the opportunity to researchers to introduce new therapeutic lines in ovarian cancer patients with promising ...
Irina Balescu, Nicoale Bacalbasa, Iulian Brezean, Claudia Stoica, Cezar Laurentiu Tomescu, Cristina Martac, Andrei Voichitoiu, Bogdan Gaspar   +7 more
doaj   +1 more source

Role of Exosomes in Epithelial–Mesenchymal Transition

ACS Applied Bio Materials, 2023
Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles,
Bikramjit Bhattacharya, Sagnik Nag, Sayantanee Mukherjee, Mrunal Kulkarni, Priti Chandane, Debashmita Mandal, Nobendu Mukerjee, Divya Mirgh, Krishnan Anand, Manab Deb Adhikari, Sukhamoy Gorai, Nanasaheb Thorat   +11 more
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H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in
Qi Hu, Jianxing Yin, Ailiang Zeng, Xin Jin, Zhuoran Zhang, Wei Yan, Yongping You   +6 more
doaj   +1 more source

Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. [PDF]

PLoS ONE, 2016
Mesenchymal-epithelial interactions play an important role in renal tubular morphogenesis and in maintaining the structure of the kidney. The aim of this study was to investigate whether extracellular vesicles (EVs) produced by human renal proximal ...
Giulia Chiabotto, Stefania Bruno, Federica Collino, Giovanni Camussi   +3 more
doaj   +1 more source

Targeting epithelial–mesenchymal transition [PDF]

Journal of Molecular Medicine, 2015
The epithelial–mesenchymal transition (EMT) is a process in which epithelial cells dedifferentiate to become mesenchymal cells [1–3]. The process requires them to lose their cell polarity, to relinquish their cell–cell adhesion, and to gain migratory and invasive properties.
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Metabolic Plasticity and Epithelial-Mesenchymal Transition [PDF]

Journal of Clinical Medicine, 2019
A major transcriptional and phenotypic reprogramming event during development is the establishment of the mesodermal layer from the ectoderm through epithelial-mesenchymal transition (EMT). EMT is employed in subsequent developmental events, and also in many physiological and pathological processes, such as the dissemination of cancer cells through ...
Timothy M. Thomson, Cristina Balcells, Marta Cascante   +2 more
openaire   +4 more sources

High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) is
Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino, Takaaki Sano, Kyoichi Ogata, Hiroyuki Kuwano, Ken Shirabe, Tetsunari Oyama   +20 more
doaj   +1 more source