Results 31 to 40 of about 87,269,478 (305)

A comparison of epithelial-to-mesenchymal transition and re-epithelialization [PDF]

Seminars in Cancer Biology, 2012
Wound healing and cancer metastasis share a common starting point, namely, a change in the phenotype of some cells from stationary to motile. The term, epithelial-to-mesenchymal transition (EMT) describes the changes in molecular biology and cellular physiology that allow a cell to transition from a sedentary cell to a motile cell, a process that is ...
Philip L, Leopold, Jan, Vincent, Hongjun, Wang   +2 more
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Clinical significance of epithelial‐mesenchymal transition [PDF]

Clinical and Translational Medicine, 2014
AbstractThe concept of epithelial‐mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research community. Thousands of scientific reports investigated changes in gene, mRNA and protein expression compatible with EMT and their possible ...
Konrad Steinestel, Stefan Eder, Andres Jan Schrader, Julie Steinestel   +3 more
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Role of Exosomes in Epithelial–Mesenchymal Transition

ACS Applied Bio Materials, 2023
Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles,
Bikramjit Bhattacharya, Sagnik Nag, Sayantanee Mukherjee, Mrunal Kulkarni, Priti Chandane, Debashmita Mandal, Nobendu Mukerjee, Divya Mirgh, Krishnan Anand, Manab Deb Adhikari, Sukhamoy Gorai, Nanasaheb Thorat   +11 more
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H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in
Qi Hu, Jianxing Yin, Ailiang Zeng, Xin Jin, Zhuoran Zhang, Wei Yan, Yongping You   +6 more
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Mesenchymal Stromal Cells Epithelial Transition Induced by Renal Tubular Cells-Derived Extracellular Vesicles. [PDF]

PLoS ONE, 2016
Mesenchymal-epithelial interactions play an important role in renal tubular morphogenesis and in maintaining the structure of the kidney. The aim of this study was to investigate whether extracellular vesicles (EVs) produced by human renal proximal ...
Giulia Chiabotto, Stefania Bruno, Federica Collino, Giovanni Camussi   +3 more
doaj   +1 more source

Targeting epithelial–mesenchymal transition [PDF]

Journal of Molecular Medicine, 2015
The epithelial–mesenchymal transition (EMT) is a process in which epithelial cells dedifferentiate to become mesenchymal cells [1–3]. The process requires them to lose their cell polarity, to relinquish their cell–cell adhesion, and to gain migratory and invasive properties.
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Metabolic Plasticity and Epithelial-Mesenchymal Transition [PDF]

Journal of Clinical Medicine, 2019
A major transcriptional and phenotypic reprogramming event during development is the establishment of the mesodermal layer from the ectoderm through epithelial-mesenchymal transition (EMT). EMT is employed in subsequent developmental events, and also in many physiological and pathological processes, such as the dissemination of cancer cells through ...
Timothy M. Thomson, Cristina Balcells, Marta Cascante   +2 more
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High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-to-mesenchymal transition (EMT) is
Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino, Takaaki Sano, Kyoichi Ogata, Hiroyuki Kuwano, Ken Shirabe, Tetsunari Oyama   +20 more
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Hydrogen peroxide enhances transforming growth factor beta-2 induced epithelial–mesenchymal transition of ARPE-19 cells

Beni-Suef University Journal of Basic and Applied Sciences, 2023
Background In the pathophysiology of the retina, the epithelial–mesenchymal transition and oxidative stress play key roles. To find a relationship between oxidative stress and diabetic retinopathy or proliferative retinopathy, we used an in-silico ...
Brijesh Gelat, Pooja Rathaur, Pooja Malaviya, Binita Patel, Abhay R. Vasavada, S. R. Kaid Johar   +5 more
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Epithelial–Mesenchymal Transition in Ovarian Carcinoma [PDF]

Frontiers in Oncology, 2012
Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression ...
Davidson, Ben, Tropé, Claes G., Reich, Reuven   +2 more
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