Results 21 to 30 of about 311,587 (357)

Vitamin D and the Epithelial to Mesenchymal Transition [PDF]

Stem Cells International, 2016
Several studies support reciprocal regulation between the active vitamin D derivative 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and ...
Larriba, María Jesús, García de Herreros, Antonio, Muñoz, Alberto   +2 more
openaire   +7 more sources

Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon

World Journal of Gastroenterology, 2012
Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinogenesis and cancer invasion, chronic ...
Ferenc Sipos, Orsolya Galamb
openaire   +3 more sources

EMT and MET: necessary or permissive for metastasis? [PDF]

, 2017
Epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead,
Gilja, Shivee, Jolly, Mohit Kumar, Levine, Herbert, Somarelli, Jason A., Ware, Kathryn E.   +4 more
core   +1 more source

Emerging roles of epithelial-mesenchymal transition in hematological malignancies

Journal of Biomedical Science, 2018
Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with ...
San-Chi Chen, Tsai-Tsen Liao, Muh-Hwa Yang   +2 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Mesenchymal Stem Cell-Like Properties in Fibroblasts

Cellular Physiology and Biochemistry, 2014
Fibroblasts are biologically dynamic and morphologically heterogeneous and are the most abundant connective tissue cells, with diverse structures depending on their location and activity.
Yuqiao Chang, He Li, Zhikun Guo
doaj   +1 more source

Epithelial‐to‐mesenchymal transitions in the liver† [PDF]

Hepatology, 2009
The outcome of liver injury is dictated by the effectiveness of repair. Successful repair (i.e., regeneration) results in replacement of dead epithelial cells with healthy epithelial cells, and reconstructs normal hepatic structure and function. Liver regeneration is known to involve replication of surviving mature hepatocytes and bile duct cells. This
Steve S. Choi, Steve S. Choi, Anna Mae Diehl   +2 more
openaire   +3 more sources

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability [PDF]

, 2018
The epithelial-to-mesenchymal transition enables carcinoma cells to acquire malignancy-associated traits and the properties of tumor-initiating cells (TICs).
Bierie, B., Kober, K. I., Krall, J. A., Pattabiraman, D. R., Reinhardt, F., Tam, W. L., Thiru, P., Zill, C.   +7 more
core   +1 more source

Epithelial-mesenchymal transitions and hepatocarcinogenesis [PDF]

Journal of Clinical Investigation, 2010
Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.
Jou, Janice, Diehl, Anna Mae
openaire   +3 more sources

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities [PDF]

, 2018
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program ...
Weinberg, Robert A., Zhang, Yun
core   +1 more source