Multistability in the epithelial-mesenchymal transition network [PDF]
BMC Bioinformatics, 2019 Abstract Background: The transitions between epithelial (E) and mesenchymal (M) cell phenotypes are essential in many biological processes like tissue development and cancer metastasis. previous studies, both modeling and experimental, suggested that in addition to E and M states, the network responsible for these phenotypes exhibits ...
Ying Xin, Bree Cummins, Tomáš Gedeon
openaire +4 more sources
Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]
, 2019 York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core +1 more source
TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) [PDF]
, 2005 Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with ...
A Atfi +50 more
core +4 more sources
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. [PDF]
PLoS ONE, 2013 The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT.
Jan Roger Olsen +12 more
doaj +1 more source
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance [PDF]
, 2019 Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage ...
Berx, Geert +3 more
core +2 more sources
Epithelial-Mesenchymal Transitions [PDF]
Cell, 2004 Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression.
Yibin Kang, Joan Massagué
openaire +3 more sources
Epithelial mesenchymal transition in human menstruation and implantation
Endocrine JournalThe endometrium during the sexual cycle undergoes detachment, tissue remodeling, and differentiation during the menstrual cycle. Localized and transient destruction and regeneration of endometrial tissue are also essential for pregnancy.
Hiroshi Uchida
doaj +1 more source
Respiratory Research, 2019 Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory ...
Jing-xiang Yang +7 more
doaj +1 more source
EMT/MET at the crossroad of stemness, regeneration and oncogenesis. The Ying-Yang equilibrium recapitulated in cell spheroids [PDF]
, 2017 The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression.
Angelini, Francesco +7 more
core +2 more sources
Epithelial to Mesenchymal Transition in a Clinical Perspective [PDF]
Journal of Oncology, 2015 Tumor growth and metastatic dissemination rely on cellular plasticity. Among the different phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been extensively illustrated. Indeed, this transition allows an epithelial polarized cell to acquire a more mesenchymal phenotype with increased mobility and invasiveness.
Jennifer Pasquier +3 more
openaire +4 more sources