Engineering Airway Epithelium [PDF]
Journal of Biomedicine and Biotechnology, 2012 Airway epithelium is constantly presented with injurious signals, yet under healthy circumstances, the epithelium maintains its innate immune barrier and mucociliary elevator function. This suggests that airway epithelium has regenerative potential (I. R. Telford and C. F. Bridgman, 1990).
John P. Soleas +4 more
openaire +3 more sources
Epithelial Cells and Inflammation in Pulmonary Wound Repair
Cells, 2021 Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, defective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or ...
Amanda Croasdell Lucchini +4 more
doaj +1 more source
Claudin-2-dependent paracellular channels are dynamically gated
eLife, 2015 Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured.
Christopher R Weber +7 more
doaj +1 more source
Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis
Frontiers in Cell and Developmental Biology, 2020 Dilation of bronchi and bronchioles caused by destruction and excessive epithelial remodeling is a characteristic feature of bronchiectasis. It is not known how epithelial progenitor cells contribute to these pathologic conditions in peripheral airways ...
Yang Peng +8 more
doaj +1 more source
Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
Cells, 2021 Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal
Martyna Cieślik +3 more
doaj +1 more source
The expression and localization of V-ATPase and cytokeratin 5 during postnatal development of the pig epididymis [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective We examined the localization and expression of H+ pumping vacuolar ATPase (V-ATPase) and cytokeratin 5 (KRT5) in the epididymis of pigs, expressed in clear and basal cells, respectively, during postnatal development.
Yun-Jae Park +9 more
doaj +1 more source
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]
, 2012 Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine +2 more
core +3 more sources
The ESRP1-GPR137 axis contributes to intestinal pathogenesis
eLife, 2017 Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease.
Lukas Franz Mager +24 more
doaj +1 more source
PM10 and Pseudomonas aeruginosa: effects on corneal epithelium
Frontiers in Cellular and Infection Microbiology, 2023 PurposeIn vivo data indicate that mouse corneas exposed to PM10 showed early perforation and thinning after infection with Pseudomonas aeruginosa. To understand the mechanisms underlying this finding, we tested the effects of PM10 and the mitochondria ...
Mallika Somayajulu +4 more
doaj +1 more source
Key Role for CRB2 in the Maintenance of Apicobasal Polarity in Retinal Pigment Epithelial Cells
Frontiers in Cell and Developmental Biology, 2021 Apicobasal polarity is essential for epithelial cell function, yet the roles of different proteins in its completion is not fully understood. Here, we have studied the role of the polarity protein, CRB2, in human retinal pigment epithelial (RPE) cells ...
Antonio E. Paniagua +7 more
doaj +1 more source