Results 151 to 160 of about 227,742 (197)

In Silico Design, Optimization, and Evaluation of a Multi-Epitope Vaccine Targeting the <i>Clostridium perfringens</i> Collagen Adhesin Protein. [PDF]

Microorganisms
Chundru D, Bhattrai S, Timilsina M, Lillehoj H, Sun Z, Ghanem M, Li C.   +6 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Early 2022 breakthrough infection sera from India target the conserved cryptic class 5 epitope to counteract immune escape by SARS-CoV-2 variants. [PDF]

J Virol
Jana ID, Kanjo K, Roy S, Bhasin M, Bhattacharya S, Banerjee I, Jana S, Chatterjee A, Chakrabarti AK, Chakraborty S, Mukherjee B, Varadarajan R, Mondal A.   +12 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Multivalent vaccine candidate from conserved immunogenic peptides in entry or exit proteins of Orthopoxvirus genus. [PDF]

Sci Rep
de Araújo LP, Silva EN, de Alencar SM, Corsetti PP, de Almeida LA.   +4 more
europepmc   +1 more source

Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection. [PDF]

Vaccines (Basel)
Li J, Ju Y, Jiang M, Li S, Yang XY.
europepmc   +1 more source

In Silico Targeting and Immunological Profiling of PpiA in <i>Mycobacterium tuberculosis</i>: A Computational Approach. [PDF]

Pathogens
Nasiri MJ, Rogowski L, Venketaraman V.
europepmc   +1 more source

Artificial intelligence in vaccine research and development: an umbrella review. [PDF]

Front Immunol
El Arab RA, Alkhunaizi M, Alhashem YN, Al Khatib A, Bubsheet M, Hassanein S.   +5 more
europepmc   +1 more source

Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8 + T cell responses. [PDF]

Sci Rep
Dam S, Tscherne A, Engels L, Sutter G, Osterhaus ADME, Rimmelzwaan GF.   +5 more
europepmc   +1 more source

Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity. [PDF]

Front Immunol
Alnajran H, Awadalla M, Aldakheel FM, Alam I, Momin AA, Alturaiki W, Alosaimi B.   +6 more
europepmc   +1 more source