Results 131 to 140 of about 326,590 (304)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epitope mapping.

, 2019
For representative mAbs, epitope mapping data are shown. (A) Binding for each mAb was quantified against a panel of 26 15-mer peptides (overlap of 3 residues) spanning the sequence of the S. aureus HU.
Stefan Ryser (4259140), Edgar Tenorio (4259128), Angeles Estellés (4259134), Lawrence M. Kauvar (4259137)   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E

Frontiers in Immunology
The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) proteins of
Simon Brackenridge, Nessy John, Klaus Früh, Persephone Borrow, Andrew J. McMichael   +4 more
doaj   +1 more source

KSA10 epitope sequencing data

, 2015
Simian Immunodeficiency Virus immune escape KSA10 epitope sequencing ...
Miles P. Davenport (68365), Kent, Stephen J., Hamid Alinejad-Rokny (518381), Stephen J. Kent (90625), Reece, Jeanette C., Alinejad-Rokny, Hamid, Cromer, Deborah, Andrew J. Grimm (249527), Shayarana L. Gooneratne (3321057), Grimm, Andrew J., Deborah Cromer (282682), Davenport, Miles P., Alexey P. Martyushev (3321060), Petravic, Janka, Jeanette C. Reece (330516), Janka Petravic (45387), Gooneratne, Shayarana L., Martyushev, Alexey P.   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

KVA10 epitope sequencing data

, 2015
Simian Immunodeficiency Virus immune escape KVA10 epitope sequencing ...
Miles P. Davenport (68365), Kent, Stephen J., Hamid Alinejad-Rokny (518381), Stephen J. Kent (90625), Reece, Jeanette C., Alinejad-Rokny, Hamid, Cromer, Deborah, Andrew J. Grimm (249527), Shayarana L. Gooneratne (3321057), Grimm, Andrew J., Deborah Cromer (282682), Davenport, Miles P., Alexey P. Martyushev (3321060), Petravic, Janka, Jeanette C. Reece (330516), Janka Petravic (45387), Gooneratne, Shayarana L., Martyushev, Alexey P.   +17 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source