Results 1 to 10 of about 287 (117)

Immunodomination during peripheral vaccinia virus infection. [PDF]

PLoS Pathogens, 2013
Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no ...
Leon C W Lin, Inge E A Flesch, David C Tscharke   +2 more
doaj   +5 more sources

Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite. [PDF]

PLoS Pathogens, 2013
CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma gondii (T. gondii) protozoan parasite. Despite the complexity of the T.
Virginie Feliu, Virginie Vasseur, Harshita S Grover, H Hamlet Chu, Mark J Brown, Jeremy Wang, Jon P Boyle, Ellen A Robey, Nilabh Shastri, Nicolas Blanchard   +9 more
doaj   +1 more source

Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure

Viruses, 2022
Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory.
Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Daniel Kelly, Rachel Williams, Sylvia Becker-Dreps, Filemón Bucardo, David J. Allen, Judith Breuer, Ralph S. Baric   +11 more
doaj   +1 more source

HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

Cell Reports, 2021
Summary: Defining factors that govern CD8+ T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the contribution of human leukocyte antigen (HLA) class-I-peptide stability for 186 optimal HIV ...
Clarety Kaseke, Ryan J. Park, Nishant K. Singh, Dylan Koundakjian, Arman Bashirova, Wilfredo F. Garcia Beltran, Overbeck C. Takou Mbah, Jiaqi Ma, Fernando Senjobe, Jonathan M. Urbach, Anusha Nathan, Elizabeth J. Rossin, Rhoda Tano-Menka, Ashok Khatri, Alicja Piechocka-Trocha, Michael T. Waring, Michael E. Birnbaum, Brian M. Baker, Mary Carrington, Bruce D. Walker, Gaurav D. Gaiha   +20 more
doaj   +1 more source

Broad-Based Influenza-Specific CD8⁺ T Cell Response without the Typical Immunodominance Hierarchy and Its Potential Implication

Viruses, 2021
Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the impact of MHC polymorphism on immunodominance in influenza A virus (IAV) infections.
Miaojuan Huang, Rong Xu, Cristina Triffon, Nicole Mifsud, Weisan Chen   +4 more
doaj   +1 more source

Identification of immunodominant T cell epitopes induced by natural Zika virus infection

Frontiers in Immunology, 2023
Zika virus (ZIKV) is a flavivirus primarily transmitted by Aedes species mosquitoes, first discovered in Africa in 1947, that disseminated through Southeast Asia and the Pacific Islands in the 2000s.
Christopher S. Eickhoff, Krystal A. Meza, Frances E. Terry, Chase G. Colbert, Azra Blazevic, Andres H. Gutiérrez, E. Taylor Stone, James D. Brien, Amelia K. Pinto, Hana M. El Sahly, Mark J. Mulligan, Nadine Rouphael, Maria L. Alcaide, Kay M. Tomashek, Chris Focht, William D. Martin, Leonard Moise, Anne S. De Groot, Anne S. De Groot, Daniel F. Hoft, Daniel F. Hoft   +20 more
doaj   +1 more source

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

Cell Reports, 2021
Summary: Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSPRepeat) can protect against malaria.
Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn   +8 more
doaj   +1 more source

Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity

Viruses, 2021
Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative vaccine remains essential for the global elimination of HCV.
Nicholas A. Brasher, Anurag Adhikari, Andrew R. Lloyd, Nicodemus Tedla, Rowena A. Bull   +4 more
doaj   +1 more source

Severe murine schistosomiasis results from disrupted CD4+ T-cell modulation by immunodominance of a single egg epitope [PDF]

Einstein (São Paulo)
Objective: This study examined the correlation between immunodominance of the major egg antigen Sm-p40234-246, a robust Th1/Th17 anti-egg CD4 T-cell response, and severe liver immunopathology in experimental murine schistosomiasis.
Eduardo Finger, Thaissa Melo Galante Coimbra, Alessandra Finardi Dastoli   +2 more
doaj   +1 more source

The Long Road to a Universal Influenza Virus Vaccine

Proceedings, 2020
Seasonal and pandemic influenza virus infections can cause significant disease worldwide. Current vaccines only provide limited, short-lived protection, and antigenic drift/shift in the hemagglutinin (HA) surface glycoprotein necessitates their annual ...
Peter Palese
doaj   +1 more source