Results 21 to 30 of about 287 (117)
TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. [PDF]
PLoS Pathogens, 2014 Many of the factors that contribute to CD8+ T cell immunodominance hierarchies during viral infection are known. However, the functional differences that exist between dominant and subdominant epitope-specific CD8+ T cells remain poorly understood.
Christa E Osuna +7 more
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Pathogens, 2021 CD8+ T-cell responses to pathogens are directed against infected cells that present pathogen-encoded peptides on MHC class-I molecules. Although natural responses are polyclonal, the spectrum of peptides that qualify for epitopes is remarkably small even
Kirsten Freitag +3 more
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Immunodominant membrane proteins of phytoplasmas
Microbiology, 2016 Phytoplasmas are plant-pathogenic, phloem-colonizing, cell wall-less microorganisms that are primarily dependent on insect transmission for their spread and survival. The life cycle of phytoplasmas involves replication in insects and host plants. Until recently, phytoplasmas have resisted all attempts at cultivation in cell-free media, making these ...
Alisa, Konnerth +2 more
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CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection
Frontiers in Immunology, 2020 West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the
Maximilian Koblischke +16 more
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A Theory of Immunodominance and Adaptive Regulation [PDF]
Bulletin of Mathematical Biology, 2010 Immunodominance refers to the phenomenon in which simultaneous T cell responses against multiple target epitopes organize themselves into distinct and reproducible hierarchies. In many cases, eliminating the response to the most dominant epitope allows responses to subdominant epitopes to expand more fully.
Kim, Peter S. +2 more
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Immunogenicity and Immunodominance in Antibody Responses [PDF]
, 2019 A large number of vaccines exist that control many of the most important infectious diseases. Despite these successes, there remain many pathogens without effective prophylactic vaccines. Notwithstanding strong difference in the biology of these infectious agents, there exist common problems in vaccine design.
Monique, Vogel, Martin F, Bachmann
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HLA‐B27: portraying immunodominant viral epitopes [PDF]
European Journal of Immunology, 2005 AbstractAlthough the crystal structure of HLA‐B27 has been known for a long time, only recently have X‐ray diffraction studies of this molecule in complex with individual peptides become available. The report of three such structures involving viral epitopes that are immunodominant in HLA‐B27‐restricted T cell responses against influenza, Epstein‐Barr ...
openaire +2 more sources
Frontiers in ImmunologyKnowledge of B cell immunodominance is important for designing vaccines that may elicit effective immune responses. However, the prevalence and characteristics of B cell immunodominance remain poorly understood.
Sungjin Choi, Dongsup Kim
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Identification of protective antigens for vaccination against systemic salmonellosis
Frontiers in Immunology, 2014 There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann
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Frontiers in Immunology, 2015 Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome.
Ingrid eSchellens +17 more
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