Results 21 to 30 of about 6,785 (163)

Immunodomination during peripheral vaccinia virus infection. [PDF]

PLoS Pathogens, 2013
Immunodominance is a fundamental property of CD8(+) T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no ...
Leon C W Lin, Inge E A Flesch, David C Tscharke   +2 more
doaj   +1 more source

Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure

Viruses, 2022
Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory.
Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Mark R. Zweigart, Samantha R. May, Daniel Kelly, Rachel Williams, Sylvia Becker-Dreps, Filemón Bucardo, David J. Allen, Judith Breuer, Ralph S. Baric   +11 more
doaj   +1 more source

Defining Antibody Immunodominance to Pandemic-Threat Viruses in Humans [PDF]

, 2021
B cell immunodominance is defined as the hierarchical antibody response to distinct antigenic proteins found in pathogens. Various factors shape the preference of antibody targeting to certain viral epitopes over others, including preexisting immunity ...
Dugan, Haley L.
core   +1 more source

Identification of immunodominant T cell epitopes induced by natural Zika virus infection

Frontiers in Immunology, 2023
Zika virus (ZIKV) is a flavivirus primarily transmitted by Aedes species mosquitoes, first discovered in Africa in 1947, that disseminated through Southeast Asia and the Pacific Islands in the 2000s.
Christopher S. Eickhoff, Krystal A. Meza, Frances E. Terry, Chase G. Colbert, Azra Blazevic, Andres H. Gutiérrez, E. Taylor Stone, James D. Brien, Amelia K. Pinto, Hana M. El Sahly, Mark J. Mulligan, Nadine Rouphael, Maria L. Alcaide, Kay M. Tomashek, Chris Focht, William D. Martin, Leonard Moise, Anne S. De Groot, Anne S. De Groot, Daniel F. Hoft, Daniel F. Hoft   +20 more
doaj   +1 more source

B cell immunodominance in primary hepatitis C virus infection [PDF]

, 2020
BACKGROUND & AIMS: Neutralising antibodies (NAbs) play a key role in clearance of HCV. NAbs have been isolated and mapped to several domains on the HCV envelope proteins.
Maher, L, Brasher, NA, Tedla, N, Lloyd, AR, Eltahla, AA, Bull, RA, Rodrigo, C, Drummer, HE, Rizzetto, S, Underwood, A, Boo, I, Walker, MR, Luciani, F   +12 more
core   +3 more sources

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

Cell Reports, 2021
Summary: Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSPRepeat) can protect against malaria.
Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn   +8 more
doaj   +1 more source

Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity

Viruses, 2021
Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative vaccine remains essential for the global elimination of HCV.
Nicholas A. Brasher, Anurag Adhikari, Andrew R. Lloyd, Nicodemus Tedla, Rowena A. Bull   +4 more
doaj   +1 more source

Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2 [PDF]

, 2021
Immunodominance is a complex and highly debated topic of T cell biology. The current SARS-CoV-2 pandemic has provided the opportunity to profile adaptive immune responses and determine molecular factors contributing to emerging responses towards ...
Kessler, Benedikt M, Wellington, Dannielle, Yin, Zixi, Dong, Tao   +3 more
core   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, IAH, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Royal (Dick) School of Veterinary Studies, ILRI, Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +44 more
core   +1 more source

The Long Road to a Universal Influenza Virus Vaccine

Proceedings, 2020
Seasonal and pandemic influenza virus infections can cause significant disease worldwide. Current vaccines only provide limited, short-lived protection, and antigenic drift/shift in the hemagglutinin (HA) surface glycoprotein necessitates their annual ...
Peter Palese
doaj   +1 more source