Results 11 to 20 of about 287 (117)
Recombinant Influenza Vaccines: Saviors to Overcome Immunodominance [PDF]
Frontiers in Immunology, 2020 It has been almost a decade since the 2009 influenza A virus pandemic hit the globe causing significant morbidity and mortality. Nonetheless, annual influenza vaccination, which elicits antibodies mainly against the head region of influenza hemagglutinin
Nimitha R. Mathew, Davide Angeletti
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Immunodominant antibody germlines in COVID-19 [PDF]
Journal of Experimental Medicine, 2021 The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?
Emanuele Andreano, Rino Rappuoli
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Defining B cell immunodominance to viruses [PDF]
Nature Immunology, 2017 Immunodominance (ID) defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody ID despite its importance in immunity to viruses and other pathogens. We show that B cells and serum antibodies from inbred mice demonstrate a reproducible ID hierarchy to the five major antigenic ...
Davide Angeletti +11 more
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Mapping Immunodominant Antibody Epitopes of Abrin [PDF]
Antibodies, 2020 Abrin, a toxin isolated from the seeds of Abrus precatorius (jequirity pea) is considered a biological threat agent by the Center for Disease Control and Prevention. To date, there is no effective postexposure treatment for abrin poisoning, and efforts are being made to develop an efficient vaccine and measures for postexposure therapy. Epitope mapping
Ron Alcalay +6 more
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Immunodominance hierarchy after seasonal influenza vaccination
Emerging Microbes & Infections, 2022 Current influenza vaccines elicit humoral immune responses against the haemagglutinin (HA) protein of influenza viruses. Different antigenic sites have been identified in the HA head as the main target of haemagglutination inhibition (HAI) antibodies (Sb, Sa, Cb, Ca1 and Ca2).
Laura Sánchez-de Prada +5 more
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CD8 memory, immunodominance, and antigenic escape [PDF]
European Journal of Immunology, 2000 Previous theoretical work has suggested that efficient virus control or clearance requires antigen-independent persistence of memory cytotoxic T lymphocyte precursors (CTLp), and that failure to generate such memory CTLp can result in persistent infection and eventual loss of virus control.
D, Wodarz, M A, Nowak
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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance
Vaccines, 2022 Humoral immunity is crucial for protection against invading pathogens. Broadly neutralizing antibodies (bnAbs) provide sterilizing immunity by targeting conserved regions of viral variants and represent the goal of most vaccination approaches.
Riccardo Biavasco, Marco De Giovanni
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T cell immunodominance is dictated by the positively selecting self-peptide
eLife, 2014 Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency ...
Wan-Lin Lo +4 more
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Vaccines, 2019 Universal influenza virus vaccine candidates that focus on the conserved hemagglutinin (HA) stalk domain and the extracellular domain of the matrix protein 2 (M2e) have been developed to increase the breadth of protection against multiple strains.
Weina Sun +4 more
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Vaccines, 2021 Influenza virus remains a serious public health burden due to ongoing viral evolution. Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit strain-specific neutralizing responses that favor the hypervariable epitopes ...
Maya Sangesland, Daniel Lingwood
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