BIDpred: unraveling B cell Immunodominance hierarchical pattern using statistical feature discovery and deep learning prediction [PDF]
Frontiers in ImmunologyKnowledge of B cell immunodominance is important for designing vaccines that may elicit effective immune responses. However, the prevalence and characteristics of B cell immunodominance remain poorly understood.
Dongsup Kim
exaly +5 more sources
Severe murine schistosomiasis results from disrupted CD4+ T-cell modulation by immunodominance of a single egg epitope [PDF]
Einstein (São Paulo)Objective: This study examined the correlation between immunodominance of the major egg antigen Sm-p40234-246, a robust Th1/Th17 anti-egg CD4 T-cell response, and severe liver immunopathology in experimental murine schistosomiasis.
Eduardo Finger +2 more
doaj +4 more sources
Cell Reports, 2021 Summary: Defining factors that govern CD8+ T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the contribution of human leukocyte antigen (HLA) class-I-peptide stability for 186 optimal HIV ...
Clarety Kaseke +20 more
doaj +2 more sources
The Relative Positioning of B and T Cell Epitopes Drives Immunodominance [PDF]
Vaccines, 2022 Humoral immunity is crucial for protection against invading pathogens. Broadly neutralizing antibodies (bnAbs) provide sterilizing immunity by targeting conserved regions of viral variants and represent the goal of most vaccination approaches.
Riccardo Biavasco, Marco De Giovanni
doaj +3 more sources
Modeling the Dependence of Immunodominance on T Cell Dynamics in Prime-Boost Vaccines [PDF]
Mathematics, 2020 The protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to long
Clemente Fernandez Arias +4 more
doaj +2 more sources
Recombinant Influenza Vaccines: Saviors to Overcome Immunodominance
Frontiers in Immunology, 2020 It has been almost a decade since the 2009 influenza A virus pandemic hit the globe causing significant morbidity and mortality. Nonetheless, annual influenza vaccination, which elicits antibodies mainly against the head region of influenza hemagglutinin
Nimitha R. Mathew, Davide Angeletti
doaj +2 more sources
Viruses, 2021 Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the impact of MHC polymorphism on immunodominance in influenza A virus (IAV) infections.
Miaojuan Huang +4 more
doaj +2 more sources
HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. [PDF]
PLoS Pathogens, 2020 Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity
Sneha Sant +13 more
doaj +4 more sources
Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies. [PDF]
Immunol RevABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Adachi Y, Takahashi Y.
europepmc +2 more sources
Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite. [PDF]
PLoS Pathogens, 2013 CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma gondii (T. gondii) protozoan parasite. Despite the complexity of the T.
Virginie Feliu +9 more
doaj +1 more source