Results 31 to 40 of about 6,785 (163)

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine Development. [PDF]

Adv Sci (Weinh)
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Huang S, Cohen KM, Chen L, Kang X, Liu C, Demouth ME, Jiang W, Maldeney AR, Tong R, Ke Z, Chandran K, Luo W, Yin Q.   +12 more
europepmc   +2 more sources

A shooting algorithm for complex immunodominance control problems [PDF]

, 2009
Although T cells are able to recognize a wide variety of target peptides, they are often strongly focused on a few of the peptides and leave the rest of them unattended.
Yang, R, Xiaopeng Zhao, Zhang, M, Ruoting Yang, Zhao, Xiaopeng, Mingjun Zhang   +5 more
core   +1 more source

T cell immunodominance is dictated by the positively selecting self-peptide

eLife, 2014
Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency ...
Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh, Paul M Allen   +4 more
doaj   +1 more source

CD8+ TCR Bias and Immunodominance in HIV-1 Infection [PDF]

, 2015
Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen.
McLaren, James Edward, Kesmir, C., Leslie, Alasdair, Gerritsen, B., Stryhn, A., Luzzi, Graz, Koofhethile, C., Kløverpris, Henrik N, Sub Theoretical Biology, Ndung'u, Thumbi, Ke mir, C., Harndahl, M., McLaren, James E, McGregor, R., Walker, B., Kloverpris, H. N., Leslie, A., McGregor, Reuben, Price, D., Ladell, Kristin, Kloverpris, Henrik N., Buus, Søren, Koofhethile, Catherine, Riddell, Lynn, Theoretical Biology and Bioinformatics, Riddell, L., Price, David A., Carlson, Jonathan M, Carlson, Jonathan M., Chen, Fabian, Goulder, P., Goulder, Philip J., Price, David A, Ndung'u, T., McLaren, James E., Walker, Bruce D., Carlson, J., Buus, Anette Stryhn, Ladell, K., Kesmir, Can, Buus, S., Harndahl, Mikkel, McLaren, J., Buus, Soren, Kløverpris, H., Luzzi, G., Goulder, Philip J, Carlson, J. M., Stryhn, Anette, Price, David, Chen, F., Walker, Bruce D, Walker, B. D., Gerritsen, Bram, Goulder, P. J.   +54 more
core   +1 more source

An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains

Vaccines, 2019
Universal influenza virus vaccine candidates that focus on the conserved hemagglutinin (HA) stalk domain and the extracellular domain of the matrix protein 2 (M2e) have been developed to increase the breadth of protection against multiple strains.
Weina Sun, Allen Zheng, Robert Miller, Florian Krammer, Peter Palese   +4 more
doaj   +1 more source

Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines

Vaccines, 2021
Influenza virus remains a serious public health burden due to ongoing viral evolution. Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit strain-specific neutralizing responses that favor the hypervariable epitopes ...
Maya Sangesland, Daniel Lingwood
doaj   +1 more source

Functional avidity-driven activation-induced cell death shapes CTL immunodominance [PDF]

, 2014
Immunodominance is a complex phenomenon that relies on a mere numerical concept, while being potentially influenced at every step of the immune response.
Biasi G, Zanovello, Paola, Ronconi E, Dalla Santa, Silvia, Milan G, Boldrin, D., Merlo A, Dalla Santa, S., Dolcetti R, Merlo, A., Bobisse, Sara, Zanovello, P., Dolcetti, R., Facchinetti, A., Biasi, Giovanni, Barbieri, V., Milan, Gabriella, Rosato, A., Milan, G., Bobisse S, Bobisse, S., Barbieri, Vito, Marin, Oriano, Marin, O., Ronconi, Elisa, Dolcetti, Riccardo, Ronconi, E., Rosato, Antonio, Boldrin D, Dalla Santa S, Merlo, Anna, Boldrin, Daniela, Facchinetti, Antonella, Biasi, G.   +33 more
core   +1 more source

TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. [PDF]

PLoS Pathogens, 2014
Many of the factors that contribute to CD8+ T cell immunodominance hierarchies during viral infection are known. However, the functional differences that exist between dominant and subdominant epitope-specific CD8+ T cells remain poorly understood.
Christa E Osuna, Ana Maria Gonzalez, Hsun-Hsien Chang, Amy Shi Hung, Elizabeth Ehlinger, Kara Anasti, S Munir Alam, Norman L Letvin   +7 more
doaj   +1 more source

Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells

Pathogens, 2021
CD8+ T-cell responses to pathogens are directed against infected cells that present pathogen-encoded peptides on MHC class-I molecules. Although natural responses are polyclonal, the spectrum of peptides that qualify for epitopes is remarkably small even
Kirsten Freitag, Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels   +3 more
doaj   +1 more source

CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection

Frontiers in Immunology, 2020
West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the
Maximilian Koblischke, Felicia S. Spitzer, David M. Florian, Stephan W. Aberle, Stefan Malafa, Ingrid Fae, Irene Cassaniti, Irene Cassaniti, Christof Jungbauer, Bernhard Knapp, Hermann Laferl, Gottfried Fischer, Fausto Baldanti, Fausto Baldanti, Karin Stiasny, Franz X. Heinz, Judith H. Aberle   +16 more
doaj   +1 more source