Results 31 to 40 of about 287 (117)
Germinal centers are permissive to subdominant antibody responses
Frontiers in ImmunologyIntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ...
Philippe A. Robert +5 more
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Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity
eLife, 2015 Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules.
Meghan O Altman +3 more
doaj +1 more source
Frontiers in Immunology, 2022 The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical ...
John C. Flickinger +9 more
doaj +1 more source
Avidity of CD8 T cells sharpens immunodominance [PDF]
International Immunology, 2007 In the course of viral infection, the immune system exploits only a fraction of the available CTL repertoire and focuses on a few of a myriad of potentially antigenic peptides. This phenomenon, known as immunodominance, depends on a number of factors, including antigen processing and transport, MHC binding, competition for antigen-presenting cells ...
Amiran H, Dzutsev +4 more
openaire +2 more sources
The control of the specificity of CD4 T cells responses: thresholds, breakpoints and ceilings
Frontiers in Immunology, 2013 It has been known for over 25 years that CD4 T cell responses are restricted to a finite number of peptide epitopes within pathogens or protein vaccines. These selected peptide epitopes are termed immunodominant.
Andrea J Sant +3 more
doaj +1 more source
Modeling the Dependence of Immunodominance on T Cell Dynamics in Prime-Boost Vaccines
Mathematics, 2020 The protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to long
Clemente Fernandez Arias +4 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley +1 more source
Identification of Immunodominant Peptides from Gnathostoma binucleatum [PDF]
The American Society of Tropical Medicine and Hygiene, 2012 Gnathostomiasis is now recognized as a zoonosis with a worldwide distribution. In the Americas, it is caused by the third-stage larvae of Gnathostoma binucleatum and in Asia mainly by G. spinigerum. The availability and preparation of specific antigens are among the main obstacles for developing reliable immunodiagnostic tests.
Samuel, Campista-León +8 more
openaire +2 more sources
Clinical & Translational Immunology, 2022 Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated protection are not well understood.
Jet van denDijssel +15 more
doaj +1 more source
T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants
Frontiers in Medicine, 2021 T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall and for viral clearance.
Thi H. O. Nguyen +7 more
doaj +1 more source