Results 51 to 60 of about 287 (117)

Humoral epitope dominance and immune imprinting by SARS‐CoV‐1 and SARS‐CoV‐2 vaccines

Immunology &Cell Biology, Volume 104, Issue 2, Page 150-167, February 2026.
We investigated Modified Vaccinia Ankara (MVA) vaccine candidates expressing the SARS‐CoV‐1 or SARS‐CoV‐2 Spike, as a primary or booster immunization, for their ability to induce antibodies targeting different epitopes on the SARS‐CoV‐2 RBD and broad cross‐reactive or cross‐neutralizing responses in C57BL/6 and antibody humanized (Ig‐humanized) mice ...
Deborah L Burnett, Ania Moxon, Anupriya Aggarwal, Katherine JL Jackson, Catherine Cotter, Anouschka Akerman, Amanda Russell, Rachel Kalman, David Langley, Jake Y Henry, Daniel Christ, Rowena A Bull, Robert Brink, Anthony D Kelleher, Hans‐Martin Jäck, Stuart Turville, Bernard Moss, Christopher C Goodnow   +17 more
wiley   +1 more source

Factors in B cell competition and immunodominance

Immunological Reviews, 2020
AbstractThe majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective antibodies are elicited to respond are not well understood. Interclonal B cell competition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in designing ...
Abbott, Robert K., Crotty, Shane
openaire   +3 more sources

Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection

Frontiers in Immunology, 2018
One of the major contributions to protective immunity to influenza viruses that is provided by virus-specific CD4 T cells is delivery of effector function to the infected lung.
Katherine A. Richards, Anthony T. DiPiazza, Anthony T. DiPiazza, Ajitanuj Rattan, Zackery A. G. Knowlden, Hongmei Yang, Andrea J. Sant   +6 more
doaj   +1 more source

ERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes

Immunology, Volume 177, Issue 2, Page 398-412, February 2026.
ERAP1 is an intracellular aminopeptidase that edits antigenic peptides to be presented by MHC class I molecules and is found in distinct functional allotypes in individuals. To investigate how different disease‐associated ERAP1 allotypes affect the cellular immunopeptidome, we generated A375 melanoma cell clones carrying either allotype 2 or allotype ...
Martha Nikopaschou, Martina Samiotaki, Anna Kannavou, Nikolaos V. Angelis, Ourania Tsitsilonis, George Panayotou, Efstratios Stratikos   +6 more
wiley   +1 more source

HLA‐DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate‐Pulsing

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT The anti‐tumour immune response plays a pivotal role in eliminating tumour cells, with the presence of tumour‐infiltrating lymphocytes (TILs) often correlated with improved patient outcomes. Among these, CD4+ T lymphocytes act as key orchestrators of the immune response, functioning as effector and regulatory cells, and are essential for ...
Gonzalo Lázaro, Juan A. Cedano, Maitane Faus, Carme Roura‐Mir, Laia Garrigós, José Pérez‐García, Javier Román‐García, Javier Cortés, Andrea Aran, Mercè Martí   +9 more
wiley   +1 more source

Immunodominant-Peptide Recognition: Beta Testing TCRαβ [PDF]

Immunity, 2008
SummaryIn this issue, Ishizuka et al. (2008) define human T cell-receptor recognition of an immunodominant influenza A matrix peptide bound to human leukocyte antigen HLA-A∗0201 in atomic detail, raising provocative questions about β chain function.
Wang, Jia-huai, Mallis, Robert J., Reinherz, Ellis L.   +2 more
openaire   +1 more source

Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Human cytomegalovirus (HCMV)‐associated ocular diseases have gained increasing attention due to a recent rise in cases diagnosed in Asia. A glycoprotein encoded by the virus UL55 gene, glycoprotein B (gB), is essential for viral entry and a primary target for naturally‐produced antibodies and vaccine development.
Tantri Lestari, Nobuyo Yawata, Gabriel Gonzalez, Hiroko Miyadera, Daisuke Motooka, Yuko Imamura, Hiroya Oki, Yasuo Mori, Mariko Shirane, Seik‐Soon Khor, Yosuke Omae, Mihoko Shimada, Dyah Ayu Windy, Satoko Nakano, Hiroki Tsutsui, Shiori Kuramoto, Chihiro Fukui, Riku Nakamura, Satoshi Yamana, Toshikatsu Kaburaki, Hisashi Mashimo, Hiroshi Takase, Ryoji Yanai, Eiichi Hasegawa, Kensuke Shibata, Makoto Yawata, Katsushi Tokunaga, Nobuyuki Ohguro, Koh‐Hei Sonoda   +28 more
wiley   +1 more source

Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza‐Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Impaired vaccination responses leave older adults more vulnerable to severe influenza (flu) infections. Pretreatment with senolytic Dasatinib and Quercertin (D + Q) did not improve vaccine responses but altered some responses to sublethal flu challenge. Despite these changes, overall flu outcomes were not impacted.
Andreia N. Cadar, Blake L. Torrance, Sofie A. Fischler, Darlene A. Djaba, Zena Haddad, Dominique E. Teskey, Nagaraju Marka, Kelsey A. Gorgei, Erica C. Lorenzo, Laura Haynes, Jenna M. Bartley   +10 more
wiley   +1 more source

Predicting HLA CD4 Immunogenicity in Human Populations

Frontiers in Immunology, 2018
BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda, Edita Karosiene, Lindy Edwards, Alba Grifoni, Sinu Paul, Massimo Andreatta, Daniela Weiskopf, John Sidney, Morten Nielsen, Morten Nielsen, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +13 more
doaj   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source