Results 41 to 50 of about 287 (117)
Cell Proliferation, EarlyView.This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai +15 more
wiley +1 more source
Insights into Api m 10‐Isoforms and Splice Variants: More Than One Major IgE‐Binding Epitope
Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.The structural, clinical and preclinical insights into Api m 10 and its immunodominant epitopes gained in this study provide substantial insights for the future development of active and passive VIT as well as further treatment approaches. ABSTRACT Background Honey bee venom (HBV) often triggers severe IgE‐mediated allergies.
Kathrin Elisabeth Paulus‐Tremel +7 more
wiley +1 more source
Dynamics of stochastic mutation to immunodominance
Mathematical Biosciences and Engineering, 2012 Although a virus contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), the immune responses against different epitopes are not uniform. Only a few CTLs (sometimes just one) will be immunodominant. Mutation of epitopes has been recognized as an important mechanism of immunodominance.
Yu Wu, Xiaopeng Zhao, Mingjun Zhang
openaire +4 more sources
mRNA Vaccination for Treating Allergy by Modulating Allergen‐Specific Immunity
iLABMED, Volume 4, Issue 1, Page 56-58, March 2026.This News and Views article discusses the rationale for anti‐allergy vaccine development using a lipid nanoparticle‐mRNA platform. The authors provide additional evidence that supports the potential of using the mRNA approach to combat allergic diseases.
Kun Guo +4 more
wiley +1 more source
Determinants of immunodominance for CD4 T cells [PDF]
Current Opinion in Immunology, 2015 The term immunodominance was originally defined as a restricted T cell response to a short peptide sequence derived from a given protein. The question of what determines immunodominance has been a longstanding battle for the past two decades. Hundreds of papers have been written on different aspects of epitope selection during antigen processing ...
AeRyon, Kim +1 more
openaire +2 more sources
Frontiers in Immunology, 2020 Dengue is an emerging mosquito-borne disease, and the use of prophylactic vaccines is still limited. We previously developed a tetravalent dengue vaccine (rMV-TDV) by a recombinant measles virus (MV) vector expressing envelope protein domain III (ED3 ...
Tsung-Han Lin +12 more
doaj +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang +12 more
wiley +1 more source
Problems and Collisions of Vaccinology
Эпидемиология и вакцинопрофилактикаThe article discusses the limitations of the protective potential of the immune system associated with the peculiarities of the evolutionary mechanisms of the emergence of protein diversity and the late emergence in the evolution of the adaptive immune ...
E. P. Kharchenko
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 2, February 2026.ABSTRACT HTLV‐1 infection is a chronic condition associated with the development of malignancies, inflammatory, and neurological disorders. In this study, the causes of hospitalization and mortality were assessed in a cohort of 508 individuals living with HTLV‐1 followed over a 30‐year period. Overall mortality was 8.5% in this population and increased
Elizabeth Souza Neves +10 more
wiley +1 more source
Viruses, 2022 Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang +23 more
doaj +1 more source