Results 41 to 50 of about 6,785 (163)

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape. [PDF]

, 2012
HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell–mediated in vivo ...
Simon Brackenridge, Korber, Bette T. M., Alan S. Perelson, Treurnicht, Florette K., Clive Gray, Hraber, Peter, Nilu Goonetilleke, Li-Hua Ping, Ferrari, Guido, Whale, Victoria., Persephone Borrow, Cohen, Myron, Peter Hraber, B, CHAVI Core, Gray, Clive M., Perelson, Alan S., Liu, Michael K.P., Abdool Karim, Salim Safurdeen., Ritchie, Adam J., Hui Li, Williamson, Carolyn., Ganusov, Vitaly., Myron Cohen, Hraber, Peter., Anderson, Jeffrey A., Jeffrey A. Anderson, CHAVI Core B, Andrew McMichael, Rachel Tanner, Gao, Feng., Goonetilleke, Nilu., Tanner, Rachel., Karim, Salim S. Abdool, Haynes, Barton, Borrow, Persephone, Williamson, Carolyn, Adam J. Ritchie, Steve Self, Ferrari, Guido., Riou, Catherine., Cai, Fangping., Whale, Victoria, Feng Gao, Bette T. Korber, Florette Treurnicht, Beatrice H. Hahn, Catherine Riou, Brackenridge, Simon, Swanstrom, Ronald, Ganusov, Vitaly V., Liu, Michael K. P., Salim S. Abdool Karim, Natalie Hawkins, Cohen, Myron S., Swanstrom, Ronald., Vitaly V. Ganusov, Self, Steven G., Michael K.P. Liu, Rose-Abrahams, Melissa, Gray, Clive, Borrow, Persephone., Riou, Catherine, Hawkins, Natalie, Treurnicht, Florette, Ping, Li-Hua, Gao, Feng, Jeffrey W. Pavlicek, Cai, Fangping, Pavlicek, Jeffrey W., Brackenridge, Simon., Li, Hui., Korber, Bette T., Carolyn Williamson, McMichael, Andrew., McMichael, Andrew, George M. Shaw, Abrahams, Melissa-Rose., Fangping Cai, Melissa Rose-Abrahams, Li, Hui, Hahn, Beatrice H., Barton Haynes, Ping, Li-Hua., Tanner, Rachel, Hawkins, Natalie., Shaw, George M., Self, Steve, Victoria Whale, Ronald Swanstrom, Haynes, Barton F., Guido Ferrari   +90 more
core   +2 more sources

What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition [PDF]

Immunol Rev
ABSTRACT Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of antibody isolation, repertoire sequencing, lineage tracing, serology, viral antigenic evolution, and structural biology have shown that antibody ...
Bonnettaz B, Bajic G.
europepmc   +2 more sources

Identification of protective antigens for vaccination against systemic salmonellosis

Frontiers in Immunology, 2014
There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann
doaj   +1 more source

Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Frontiers in Immunology, 2015
Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome.
Ingrid eSchellens, Ingrid eSchellens, Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Sanne eSpijkers, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Debbie eVan Baarle, Debbie eVan Baarle, Cecile A.C.M. Van Els   +17 more
doaj   +1 more source

Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

eLife, 2015
Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules.
Meghan O Altman, Jack R Bennink, Jonathan W Yewdell, Brantley R Herrin   +3 more
doaj   +1 more source

Influence of Immunodominance on Viral Evolution.

, 2013
(A) The distribution of CTL clones plotted as a function of . Lower values of yield a broad repertoire of CTL clones that are similar in size whereas for higher the degree of immunodominance increases.
Christian L. Althaus (112118), Rob J. De Boer (5650318)   +1 more
core   +1 more source

Germinal centers are permissive to subdominant antibody responses

Frontiers in Immunology
IntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ...
Philippe A. Robert, Philippe A. Robert, Theinmozhi Arulraj, Theinmozhi Arulraj, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Immunodominance in TCD8+ Responses to Viruses Cell Biology, Cellular Immunology, and Mathematical Models [PDF]

, 2004
Highlights from a Fundación Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses. A central feature of antiviral TCD8+ responses is immunodominance: out of thousands of potential target peptides, only a ...
Del Val, Margarita, Yewdell, Jonathan W.
core   +1 more source

T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C

Frontiers in Immunology, 2022
The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical ...
John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D. Carlson, Joshua R. Barton, Scott A. Waldman, Scott A. Waldman, Adam E. Snook, Adam E. Snook, Adam E. Snook   +9 more
doaj   +1 more source

Examination of HY response:T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis

, 2001
We have applied MHC class I tetramers representing the two H2(b) MHC class I-restricted epitopes of the mouse male-specific minor transplantation Ag, HY, to directly determine the extent of expansion and immunodominance within the CD8+ T cell compartment
Simpson, E., Chandler, P., Dazzi, F.; id_orcid, Dyson, P. J., Scott, D., Millrain, M.   +5 more
core   +5 more sources