Results 61 to 70 of about 6,785 (163)

Problems and Collisions of Vaccinology

Эпидемиология и вакцинопрофилактика
The article discusses the limitations of the protective potential of the immune system associated with the peculiarities of the evolutionary mechanisms of the emergence of protein diversity and the late emergence in the evolution of the adaptive immune ...
E. P. Kharchenko
doaj   +1 more source

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Viruses, 2022
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu   +23 more
doaj   +1 more source

The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT CD4+ T cells orchestrate adaptive immunity against respiratory viruses through functionally distinct subsets, yet the qualitative differences between vaccine‐ and infection‐induced responses remain incompletely understood. This review summarizes current evidence on how CD4+ T cell subsets shape the magnitude, breadth, and durability of ...
Masato Kubo
wiley   +1 more source

Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.

, 2011
Grafts can be rejected even when matched for MHC because of differences in the minor histocompatibility Ags (mH-Ags). H4- and H60-derived epitopes are known as immunodominant mH-Ags in H2(b)-compatible BALB.B to C57BL/6 transplantation settings. Although
Subramaniam Malarkannan, Malarkannan, Subramaniam, Kwun, Jean, William J. Burlingham, Knechtle, Stuart J, Stuart J. Knechtle, Burlingham, William J, Jean Kwun   +7 more
core   +1 more source

Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection

Frontiers in Immunology, 2018
One of the major contributions to protective immunity to influenza viruses that is provided by virus-specific CD4 T cells is delivery of effector function to the infected lung.
Katherine A. Richards, Anthony T. DiPiazza, Anthony T. DiPiazza, Ajitanuj Rattan, Zackery A. G. Knowlden, Hongmei Yang, Andrea J. Sant   +6 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

GC B Cells, Tfh Cells, and Influenza bnAbs: Insights for Improving Universal Vaccine Design

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Antibodies are crucial for providing protection against influenza virus infection; however, protective humoral immunity is limited by antigenic drift and shift. Hence, the discovery of broadly neutralizing antibodies (bnAbs) targeting conserved epitopes on hemagglutinin protein evokes the hope of developing a universal influenza vaccine ...
Takeshi Inoue, Wataru Ise, Tomohiro Kurosaki   +2 more
wiley   +1 more source

Reversal of immunodominance among autoantigenic T-cell epitopes.

, 1999
Studies spanning several decades have revealed how the complex forces of antigen processing distinguish those epitopes of a protein that dominate the immune response from those that remain cryptic.
Fairchild, Paul, Fairchild, PJ, Paul J. Fairchild   +2 more
core   +1 more source

The TG2/LRP1 Pathway for T Cell Activation by Post‐Translationally Modified Antigens

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Post‐translational modifications (PTMs) can generate neo‐epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post‐translationally modified peptides with their effective presentation as T‐cell antigens by dendritic cells.
Agnele Sylvia Sewa, Fu‐Chen Yang, Chaitan Khosla   +2 more
wiley   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source